Objectives: The effects of antibiotics on the microbiome remain incompletely understood. Azithromycin (AZ) has been shown to improve child survival and infant growth outcomes. This study aimed to assess the impact of AZ on B. infantis colonization and bacterial enteropathogen count in the infant gut.
Methods: We analyzed clinical, biomarker, B. infantis and enteropathogen data from 150 mother-infant dyads from the MUMTA Lactating Women study. Colonization of B. infantis was assessed using quantitative PCR of fecal samples. We utilized a customized PCR-based TaqMan Array Card (TAC) for enteropathogen detection.
Results: AZ administration was associated with a 1.99-fold (95% CI 1.33-2.97) increase in colonization by B. infantis. B. infantis colonization was highest when inflammatory biomarker levels were within normal range. Mode of delivery (RR 2.43; 95% CI: 1.58, 3.76) and colostrum (RR2.05; 95% CI: 1.41, 2.98) given to the infant within 24 hours of birth were associated with B. infantis colonization. A single dose of AZ on day 42 reduced bacterial enteropathogen count in the AZ group on day 56, as compared to the pre-AZ count. Bacterial enteropathogen count for infants with wasting (Weight for length Z-score WLZ<-2) was 1.43-fold higher (95% CI: 1.00-2.03) than for infants with WLZ≥ -2. Over 60% of infants harboured with the macrolide resistance mph(A) gene CONCLUSIONS: AZ administration increases B. infantis colonization and reduces bacterial enteropathogen count in infants.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijid.2025.107794 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of one prophylactic dose of Azithromycin on Bifidobacterium infantis colonization in infants from the Mumta Trial.
Int J Infect Dis
January 2025
Department of Paediatrics and Child Health, The Aga Khan University. Electronic address:
Objectives: The effects of antibiotics on the microbiome remain incompletely understood. Azithromycin (AZ) has been shown to improve child survival and infant growth outcomes. This study aimed to assess the impact of AZ on B.
View Article and Find Full Text PDFLayer-by-layer coated probiotics with tannic acid-Ca and casein phosphopeptide complexes for caries prevention and enamel remineralization.
iScience
January 2025
Department of Orthodontics, Tianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, No.12 Qixiangtai Road, Heping District, Tianjin 300070, P.R. China.
Dental caries is a common disease resulting from tooth demineralization caused by bacterial plaque. Probiotics have shown great potential against caries by regulating the balance of oral flora. However, obstacles such as poor colonization and lysozyme sensitivity in oral cavity hinder their further application.
View Article and Find Full Text PDFInsights into Within-Host Evolution and Dynamics of Oral and Intestinal Streptococci Unveil Niche Adaptation.
Int J Mol Sci
December 2024
Division of Oral Microbiology and Immunology, Department of Operative Dentistry, Periodontology and Preventive Dentistry, Rheinisch-Westfälische Technische Hochschule (RWTH) University Hospital, 52074 Aachen, Germany.
The oral-gut axis is a complex system linking the oral cavity and gastrointestinal tract, impacting host health and microbial composition. This study investigates genetic changes and adaptive mechanisms employed by streptococci-one of the few genera capable of colonizing oral and intestinal niches-within the same individual. We conducted whole-genome sequencing (WGS) on 218 streptococcal isolates from saliva and fecal samples of 14 inflammatory bowel disease (IBD) patients and 12 healthy controls.
View Article and Find Full Text PDFcharacterization and genome sequencing of two novel lytic phages against Infantis isolated from poultry feces.
Front Microbiol
December 2024
Experimental Zooprophylactic Institute of Abruzzo and Molise "G. Caporale", Teramo, Italy.
Introduction: spp. is the second most common bacteria associated with foodborne gastrointestinal outbreaks in humans, with the highest contamination levels in meat, especially poultry. subsp.
View Article and Find Full Text PDFIsolation and characterization of Bifidobacterium spp. from breast milk with different human milk oligosaccharides utilization and anti-inflammatory capacity.
Food Res Int
November 2024
School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China; Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, Xi'an, Shaanxi 710061, China. Electronic address:
Article Synopsis
- Breast milk is essential for infant nutrition, and specific Bifidobacterium strains can enhance health by utilizing human milk oligosaccharides (HMOs).
- The study successfully isolated nine Bifidobacterium strains from breast milk, which demonstrated strong probiotic potential through various beneficial activities and safety profiles.
- Notably, B. breve N-90 and B. infantis R-1 were identified as promising candidates for probiotic inclusion in simulated maternal milk formulas due to their effective utilization of HMOs and anti-inflammatory properties.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!