To develop and validate a novel multidimensional readout method that significantly reduces the number of readout channels in PET detectors while maintaining high spatial and energy performance. Approach: We arranged a 3×3×4 SiPM array in multiple dimensions and employed row/column/layer summation with a resistor-based splitting circuit. We then applied denoising methods to enhance the peak-to-valley ratio in the decoding map, ensuring accurate crystal-position determination. Additionally, we investigated the system's energy response at 511 keV and evaluated the suitability for both clinical and research PET systems. Main Results: The proposed multidimensional readout method achieved a favorable multiplexing ratio, lowering the total number of readout channels without compromising energy resolution at 511 keV. Our tests demonstrated that a SiPM bias voltage of 31 V effectively balances gain and saturation effects, resulting in reliable energy measurements. Significance: By reducing system complexity, cost, and power consumption, the multidimensional readout method presents a practical alternative to conventional readout schemes for PET and other large-scale sensor arrays. Additionally, the approach can manage simultaneous multi-layer hits by arranging detector layers and, when needed, uses ICS detection to correct for scatter events. Its adaptable architecture allows scaling to higher dimensions for broader applications (e.g., SPECT, CT, LiDAR). These features make it a valuable contribution toward more efficient, high-performance imaging technologies in both clinical and industrial settings.
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http://dx.doi.org/10.1088/1361-6560/adae4c | DOI Listing |
Phys Med Biol
January 2025
Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Guangqiao Load, Shenzhen, 518132, CHINA.
To develop and validate a novel multidimensional readout method that significantly reduces the number of readout channels in PET detectors while maintaining high spatial and energy performance. Approach: We arranged a 3×3×4 SiPM array in multiple dimensions and employed row/column/layer summation with a resistor-based splitting circuit. We then applied denoising methods to enhance the peak-to-valley ratio in the decoding map, ensuring accurate crystal-position determination.
View Article and Find Full Text PDFALTEX
January 2025
In vitro toxicology and biomedicine, inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.
On occasion of the DNT5 meeting in Konstanz, Germany (April-2024), participants brainstormed on future challenges concerning a regulatory implementation of the developmental neurotoxicity (DNT) in vitro test battery (DNT-IVB). The five discussion topics below outline some of the key issues, opportunities and research directions for the next several years: (1) How to contextualize DNT hazard with information on potential maternal toxicity or other toxicity domains (non-DNT)? Several approaches on how to use cytotoxicity data from NAMs were discussed. (2) What opportunities exist for an immediate or near-future application of the DNT-IVB, e.
View Article and Find Full Text PDFFood Chem
March 2025
School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, PR China; Shandong Key Laboratory of Biochemical Analysis, Qingdao University of Science and Technology, Qingdao 266042, PR China; State Environmental Protection Key Laboratory of Monitoring for Heavy Metal Pollutants, Hunan Ecology and Environment Monitoring Center, Changsha 410019, PR China; Fujian Key Laboratory of Functional Marine Sensing Materials, Minjiang University, Fuzhou 350108, PR China. Electronic address:
With the popularity of health-conscious tea drinking, precise sensing of polyphenols as a main class of antioxidants in tea becomes critical for tea authentication and brewing evaluation. Sensor arrays show great potential for the goal, but currently available sensor arrays always need multiple sensing units and/or multi-dimensional signals, resulting in cumbersome sensor construction and operation as well as data processing. Developing easy-to-fabricate and easy-to-use sensor arrays for efficient discrimination is still challenging.
View Article and Find Full Text PDFJ Chem Phys
October 2024
Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
Action spectroscopies use a readout created by the action of light on the molecules or material rather than optical absorption. Ultrafast 2D photocurrent and 2D fluorescence spectroscopies are two such action spectroscopies. Despite their utility, multidimensional action spectroscopies suffer from a background created by incoherent population mixing.
View Article and Find Full Text PDFNanoscale
November 2024
Department of Physics, University of Aveiro, 3810-193 Aveiro, Portugal.
Luminescence thermometry presents precise remote temperature measurement capabilities but faces significant challenges in real-world applications, primarily stemming from the calibration's susceptibility to environmental factors. External factors can compromise accuracy, necessitating resilient measurement protocols to ensure dependable temperature (T) readings across various settings. We explore a novel three-dimensional (3D) approach based on time-gated (t) luminescence thermometric parameters, (,), employing physical mixtures of surface-engineered carbon dots (CDs) based on dibenzoylmethane and rhodamine B.
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