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Alitretinoin is not a suitable treatment for the majority of chronic hand eczema patients.
J Eur Acad Dermatol Venereol
February 2025
Inserm U1111, Centre International de Recherche en Infectiologie, Lyon, France.
Alitretinoin as a Treatment Modality for Ichthyosis in Women of Childbearing Age: A Case Series and Review of the Literature.
Dermatology
February 2024
Department of Dermatology, Maastricht University Medical Centre +, Maastricht, The Netherlands.
Article Synopsis
- Acitretin, a common oral treatment for ichthyosis, requires extended contraceptive measures post-treatment, posing challenges for women of childbearing age; alitretinoin is suggested as a safer alternative that allows pregnancy one month after stopping the medication.
- A study involved nine women aged 19-31 with various ichthyosis types, treated with alitretinoin for 2-28 months, showing significant improvements in skin severity scores.
- Side effects were generally mild and reversible; literature search revealed that most previous studies on alitretinoin for ichthyosis also reported significant improvements, indicating its potential as a valuable treatment option.
Alitretinoin reduces erythema in inherited ichthyosis.
Orphanet J Rare Dis
April 2018
Reference Centre for Rare Skin Diseases, Dermatology Department, CHU Larrey, Paul Sabatier University, 24, Chemin de Pouvourville, 31400, Toulouse, Cedex 09, France.
Background: Acitretin is the main retinoid used to treat severe inherited ichthyosis. Alternatives may be considered if it results ineffective or there are side-effects, or for women of childbearing age. Our objective is evaluation of the effects and tolerance of alitretinoin.
View Article and Find Full Text PDFEfficacy and safety of oral alitretinoin in severe oral lichen planus--results of a prospective pilot study.
J Eur Acad Dermatol Venereol
February 2016
Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Background: Patients with severe oral lichen planus refractory to standard topical treatment currently have limited options of therapy suitable for long-term use. Oral alitretinoin (9-cis retinoic acid) was never systematically investigated in clinical trials, although case reports suggest its possible efficacy.
Objectives: To assess the efficacy and safety of oral alitretinoin taken at 30 mg once daily for up to 24 weeks in the treatment of severe oral lichen planus refractory to standard topical therapy.
Rapid determination of retinoic acid and its main isomers in plasma by second-order high-performance liquid chromatography data modeling.
Anal Bioanal Chem
December 2014
Laboratorio de Desarrollo Analítico y Quimiometría (LADAQ), Cátedra de Química Analítica I, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral-CONICET, Ciudad Universitaria, 3000, Santa Fe, Argentina.
This paper reports the development of a method based on high-performance liquid chromatography (HPLC) coupled to second-order data modeling with multivariate curve resolution-alternating least-squares (MCR-ALS) for quantification of retinoic acid and its main isomers in plasma in only 5.5 min. The compounds retinoic acid (RA), 13-cis-retinoic acid, 9-cis-retinoic acid, and 9,13-di-cis-retinoic acid were partially separated by use of a Poroshell 120 EC-C18 (3.
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