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The conundrum of antifungal resistance: Emergence of Nakaseomyces glabratus (Candida glabrata) in Europe with global implications.
J Eur Acad Dermatol Venereol
February 2025
Mediprobe Research Inc., London, Ontario, Canada.
Outcomes of Coccidioides Seropositive Solid Organ Transplant Recipients After Self-discontinuation of Antifungal Prophylaxis: The EIA-IgM-only Conundrum.
Transplantation
January 2025
Division of Infectious Diseases, Mayo Clinic, Phoenix, AZ.
Background: Solid organ transplant recipients are at risk of severe coccidioidomycosis and are given prophylaxis to mitigate the risk. Patients with seropositive testing typically receive lifelong prophylaxis; currently, this prophylaxis strategy includes patients who are positive only for IgM by enzyme immunoassay (EIA-IgM-only), although this result may be falsely positive.
Methods: We conducted a retrospective study at a large-volume transplant center in an endemic coccidioidomycosis region to compare outcomes of non-lung transplant recipients who were seropositive for Coccidioides but discontinued prophylaxis (case patients) to outcomes of patients who continued prophylaxis (controls).
Viral proteins resolve the virus-vector conundrum during hemipteran-mediated transmission by subverting salicylic acid signaling pathway.
Nat Commun
November 2024
Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insects, Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, 310058, Hangzhou, China.
Hemipteran insects transmit viruses when infesting plants, during which vectors activate salicylic acid (SA)-regulated antiviral defenses. How vector-borne plant viruses circumvent these antiviral defenses is largely unexplored. During co-infections of begomoviruses and betasatellites in plants, betasatellite-encoded βC1 proteins interfere with SA signaling and reduce the activation of antiviral resistance.
View Article and Find Full Text PDFFatty acid synthase inhibitor cerulenin hinders liver cancer stem cell properties through FASN/APP axis as novel therapeutic strategies.
J Lipid Res
November 2024
Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; International Master/Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:
Hepatocellular carcinoma (HCC) poses significant treatment challenges due to high postoperative recurrence rates and the limited effectiveness of targeted medications. Researchers have identified the unique metabolic profiles of cancer stem cells (CSCs) as the primary drivers of cancer recurrence, metastasis, and drug resistance. Therefore, to address the therapeutic conundrum, this study focused on rewinding metabolic reprogramming of CSCs as a novel therapeutic strategy.
View Article and Find Full Text PDFShould Empiric Anti-Fungals Be Administered Routinely for All Patients with Perforated Peptic Ulcers? A Critical Review of the Existing Literature.
Pathogens
June 2024
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.
Article Synopsis
- - A perforated peptic ulcer (PPU) is a critical surgical emergency that can lead to severe complications like secondary peritonitis, with patient outcomes heavily influenced by pre-existing health conditions and the effectiveness of subsequent surgery.
- - While surgery and continued resuscitation are primary treatments, the use of empiric antibiotics is common; however, the role of empiric antifungal treatments remains uncertain due to insufficient scientific evidence and mixed study results.
- - Identifying whether a patient has a fungal infection versus mere fungal presence is crucial, and future research should focus on selecting patients who could benefit from antifungal therapy, potentially guided by new fungal biomarkers and multidisciplinary team discussions.
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