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From Copenhagen chill to desert heat thrill.
Exp Physiol
January 2025
Department of Nutrition, Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark.
A register and questionnaire study of long-term general health symptoms following SARS-CoV-2 vaccination in Denmark.
NPJ Vaccines
March 2024
Department of Epidemiology Research, Statens Serum Institut, 2300, Copenhagen, Denmark.
Many individuals who refuse COVID-19 vaccination have concerns about long-term side effects. Here, we report findings on self-reported symptoms from a Danish survey- and register study. The study included 34,868 vaccinated primary course recipients, 95.
View Article and Find Full Text PDFValidating an advanced smartphone application for thermal advising in cold environments.
Int J Biometeorol
December 2023
Thermal Environment Laboratory, Division of Ergonomics and Aerosol Technology, Department of Design Sciences, Lund University, Sölvegatan 26, 223 62, Lund, Sweden.
The ClimApp smartphone application was developed to merge meteorological forecast data with personal information for individualized and improved thermal warning during heat and cold stress and for indoor comfort in buildings. For cold environments, ClimApp predicts the personal thermal stress and strain by the use of the Insulation REQuired model that combines weather and personal physiological data with additional consideration of the Wind Chill index based on the local weather forecast. In this study, we validated the individualized ClimApp index relative to measurements and compared it with the Universal Temperature Climate Index (UTCI).
View Article and Find Full Text PDFESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies.
Intensive Care Med
July 2023
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Article Synopsis
- The guidelines aim to update the 2017 clinical practice guideline (CPG) from the European Society of Intensive Care Medicine (ESICM), focusing on adult patients with acute respiratory distress syndrome (ARDS), including cases related to COVID-19.
- An international panel of clinical experts collaborated to create these guidelines, using established methods like the PRISMA statement for systematic reviews and the GRADE approach for assessing evidence quality and making recommendations.
- The CPG responds to 21 specific questions and offers recommendations across several areas, such as respiratory support strategies (like high-flow nasal cannula and non-invasive ventilation) and includes expert opinions on clinical practices and future research directions.
BRAFV600E alterations are prevalent across multiple tumors. Here we present final efficacy and safety results of a phase 2 basket trial of dabrafenib (BRAF kinase inhibitor) plus trametinib (MEK inhibitor) in eight cohorts of patients with BRAFV600E-mutated advanced rare cancers: anaplastic thyroid carcinoma (n = 36), biliary tract cancer (n = 43), gastrointestinal stromal tumor (n = 1), adenocarcinoma of the small intestine (n = 3), low-grade glioma (n = 13), high-grade glioma (n = 45), hairy cell leukemia (n = 55) and multiple myeloma (n = 19). The primary endpoint of investigator-assessed overall response rate in these cohorts was 56%, 53%, 0%, 67%, 54%, 33%, 89% and 50%, respectively.
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