Unlabelled: This study has the objective to translate the Cornell Assessment of Pediatric Delirium (CAPD) into Indonesian and evaluate the psychometric properties and diagnostic accuracy of the Indonesian version of the CAPD (I-CAPD) in identifying delirium in critically ill children. This prospective methodological study was conducted between January and April 2024 in a 6-bed pediatric intensive care unit (PICU). In total, 90 children aged 0-18 years hospitalized in the PICU were included. Bedside nurses administered the I-CAPD every shift, while delirium diagnoses were confirmed by a psychiatrist by using the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria. A receiver operating characteristic (ROC) curve analysis was conducted to examine the sensitivity and specificity of the I-CAPD. The mean age was 8 years, with 53% being girl. According to DSM-5 criteria, 55.6% of the children had PICU delirium. Cronbach's α and interclass correlation coefficient for the I-CAPD were 0.94 and 0.94, respectively. The I-CAPD exhibited a single-factor structure accounting for 72% of the total variance. The I-CAPD was significantly associated with pain assessments (r = 0.32, P < 0.001). The ROC curve analysis indicated an optimal cutoff of ≥ 9, with the sensitivity, specificity, and area under curve of 92%, 93%, and 0.96, respectively.
Conclusion: The I-CAPD demonstrates reliable psychometric properties and diagnostic accuracy for detecting delirium in critically ill children. Future studies should explore the impact of routine I-CAPD screening on clinical outcomes and targeted interventions for pediatric delirium.
What Is Known: • Delirium in pediatric intensive care units (PICUs) is prevalent and associated with adverse outcomes, yet its diagnosis remains challenging, particularly in low-resource settings. • The Cornell Assessment of Pediatric Delirium (CAPD) has been validated in multiple languages and contexts but has not been adapted for use in Indonesian-speaking populations.
What Is New: • This study demonstrates the successful translation and psychometric evaluation of the Indonesian version of the CAPD (I-CAPD), confirming its reliability and validity in identifying delirium in critically ill Indonesian children. • The I-CAPD provides a standardized tool with high diagnostic accuracy (sensitivity: 92%; specificity: 93%) for routine delirium screening in Indonesian PICUs.
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http://dx.doi.org/10.1007/s00431-025-05984-2 | DOI Listing |
Mol Cell Pediatr
January 2025
Pediatrics Department, Khyber Teaching Hospital, Peshawar, Pakistan.
Background: Patent ductus arteriosus is one of the most common cardiac conditions affecting the neonates. Considering the lack of studies done on this topic in healthcare settings in Khyber Pakhtunkhwa province, this study aims to find out the comparative effectiveness of paracetamol and ibuprofen in management of PDA in our healthcare setting to conclude a better management option for the condition.
Objective: To find and compare the effectiveness of paracetamol and ibuprofen in the closure of patent ductus arteriosus in preterm neonates.
Eur J Clin Microbiol Infect Dis
January 2025
Laboratory of Medical Microbiology, Ghent University Hospital, Ghent, Belgium.
Purpose: Mortality and morbidity of patients with bloodstream infection (BSI) remain high despite advances in diagnostic methods and efforts to speed up reporting. This study investigated the impact of reporting rapid Minimum Inhibitory Concentration (MIC)-results in Gram negative BSIs with the ASTar system (Q-linea, Uppsala, Sweden) on the adaptation of empirically started antimicrobial therapy. We performed a real-world study during which antimicrobial susceptibility testing (AST) results were instantly reported to the treating physician in an established multidisciplinary antimicrobial stewardship setting.
View Article and Find Full Text PDFViruses
January 2025
Pediatric Unit, Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, Via Consolare Valeria 1, 98124 Messina, Italy.
Background: Bronchiolitis is the most common cause of lower respiratory tract infection (LRTI) in the first year of life. We analyzed the association between complete blood count (CBC), c-reactive protein (CRP), and novel inflammatory indexes (NLR, PLR, MLR, ELR, LMR, NPR, LPR, LNR, PNR, SII, SIRI) in predicting bronchiolitis severity at hospital admission.
Methods: We retrospectively collected data from 95 infants hospitalized for bronchiolitis in a third-level hospital during three epidemic seasons.
Nutrients
January 2025
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Background/objectives: This protocol describes a study to investigate the feasibility and preliminary efficacy of a novel Teaching Kitchen Multisite Trial (TK-MT) for adults with cardiometabolic abnormalities. The TK-MT protocol describes a hybrid lifestyle intervention combining in-person and virtual instruction in culinary skills, nutrition education, movement, and mindfulness with community support and behavior change strategies. This 18-month-long randomized controlled trial aims to evaluate the feasibility of implementing a 12-month, 24 class program, assess preliminary study efficacy, and identify barriers and facilitators to implementation.
View Article and Find Full Text PDFNutrients
January 2025
Department of Pediatric Intensive Care, Faculty of Medicine, Mugla Sitki Kocman University, Mugla 48000, Türkiye.
Background: The inability to ensure adequate nutrition for patients, and failure to provide adequate calorie and protein intake, result in malnutrition, leading to increased morbidity and mortality. The present study assesses the two approaches to enteral nutrition-intermittent and continuous enteral feeding-in critically ill pediatric patients in Türkiye to determine the superiority of one method over the other.
Methods: Included in this multicenter prospective study were patients receiving enteral nutrition via a tube who were followed up over a 3-month period.
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