The capture of magnetic nanoparticles (MNPs) is essential in the separation and detection of MNPs for applications such as magnetic biosensing. The sensitivity of magnetic biosensors inherently depends upon the distribution of captured MNPs within the sensing area. We previously demonstrated that the distribution of MNPs captured from evaporating droplets by ferromagnetic antidot nanostructures can be controlled via an external magnetic field. In this paper, we demonstrate the capture of magnetic nanoparticles from a microfluidic flow by four variants of antidot array nanostructures etched into 30 nm thick Permalloy films. The nanostructures were exposed to 130 nm MNP clusters passing through microfluidic channels with square cross-sections of 400 μm × 400 μm. In the presence of a parallel magnetic field, up to 83.1% of nanoparticles were captured inside the antidot holes. Significantly higher proportions of nanoparticles were captured within the antidots from the flow than when applying the nanoparticles via droplets. In the parallel field configuration, MNPs can be focused into the regularly spaced antidot indents in the nanostructure, which may be useful when detecting or observing MNPs and their conjugates. Conversely, up to 84% of MNPs were caught outside of antidots under a perpendicular magnetic field. Antidot nanostructures under this perpendicular configuration show potential for MNP filtration applications.
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http://dx.doi.org/10.3390/nano15020132 | DOI Listing |
Comput Biol Med
January 2025
Emerging Technologies Research Lab (ETRL), College of Computer Science and Information Systems, Najran University, Najran, 61441, Saudi Arabia; Department of Computer Science, College of Computer Science and Information Systems, Najran University, Najran, 61441, Saudi Arabia. Electronic address:
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View Article and Find Full Text PDFMaterials (Basel)
January 2025
Life Sciences Division, National Research Council of Canada, 75 de Mortagne Boulevard, Boucherville, QC J4B 6Y4, Canada.
A novel approach to protein quantification utilizing a microfluidic platform activated by a magnetic assembly of functionalized magnetic beads around soft magnetic capture centers is presented. Functionalized magnetic beads, known for their high surface area and facile manipulation under external magnetic fields, are injected inside microfluidic channels and immobilized magnetically on the surface of glass-coated soft magnetic microwires placed along the symmetry axis of these channels. A fluorescent (Cy5) immunomagnetic sandwich ELISA is then performed by sequentially flowing the sample and all necessary reagents in the microfluidic channels.
View Article and Find Full Text PDFMicromachines (Basel)
December 2024
Mechatronics Engineering Department, Istanbul Ticaret University, 34854 Maltepe, Turkey.
An automated micro-tweezers system with a flexible workspace would benefit the intelligent sorting of live cells. Such micro-tweezers could employ a forced vortex strong enough to capture a single cell. Furthermore, addressable control of the position to the vortex would constitute a robotic system.
View Article and Find Full Text PDFNat Mater
January 2025
Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.
Van der Waals materials display rich structural polymorphs with distinct physical properties. An atomistic understanding of the phase-transition dynamics, propagation pathway and associated evolution of physical properties is essential for capturing their potential in practical technologies. However, direct visualization of the rapid phase-transition process is fundamentally challenging due to the inherent trade-offs among atomic resolution, field of view and imaging frame rate.
View Article and Find Full Text PDFEnviron Res
January 2025
Key Laboratory of Poyang Lake Environment and Resource Utilization, Ministry of Education, School of Resources and Environment, Nanchang University, Nanchang, 330031, PR China.
Antibiotics and heavy metals pose severe risks to human health and ecological environment. Therefore, developing a multifunctional adsorbent to remove these contaminants from wastewater is an urgent need. Herein, novel anionic sulfonic acid groups functionalized magnetic β-cyclodextrin (β-CD) composites (FCD@AA) were synthesized by coating poly(2-acrylamido-2-methyl-1-propane sulfonic acid (AMPS)) on the surface of magnetic β-CD particles (FCD).
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