Background/objectives: Loneliness is a heterogeneous phenomenon, generally defined as an emotional experience based on the perceived distance between an individual's actual social relationships and those he or she would like to have. Adolescence is particularly vulnerable to loneliness because of the many changes in values, feelings, and emotions that characterize it. Among the aspects that may influence this feeling of discomfort, the literature identifies maladaptive personality and a dysfunctional response to traumatic events. Our study aims to identify the possible role that maladaptive personality traits and post-traumatic stress symptomatology in the form of Post-Traumatic Stress Disorder (PTSD) and Disturbance in Self-Organization (DSO) may play in the perception of loneliness in adolescents: Methods: We identified a mediation model constructed through structural equation modeling (SEM) to test PTSD and DSO post-traumatic stress symptomatology as independent variables and maladaptive personality as a mediator in the relationship between these and perceptions of loneliness in a population of adolescents of both sexes, Italian high school students; Results: Our study identifies the significant role of PTSD and DSO symptomatology in influencing the state of loneliness, both directly and indirectly through maladaptive personality traits, which appear to exert a substantial influence on the perception of loneliness, potentially functioning as mediators in the relationship between the latter and PTSD/DSO symptomatology. Presumably, a maladaptive personality may complicate recovery from adverse and traumatic experiences by preventing the implementation of functional coping strategies and promoting dysfunctional responses.
Conclusions: Our findings underscore the importance of researchers and clinicians adequately considering different personality traits and the early identification of post-traumatic stress symptomatology. A focus on adolescents' communication and interpersonal skills and their ability to respond effectively to stressful and traumatic events may prove useful in identifying more effective strategies for preventing and managing loneliness and related distress in adolescents.
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http://dx.doi.org/10.3390/brainsci15010086 | DOI Listing |
J Clin Med
January 2025
Experimental Anatomy Research Group, Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
Low back pain (LBP) is the leading cause of disability worldwide, resulting in enormous socio-economic and personal consequences. Sensory profiles during the acute back pain stage will predict central sensitization symptoms in the chronic pain stage, as central sensitization is the main mechanism behind nociplastic pain and pain chronicity. Therefore, our objective was to establish overall and sex-specific sensory profile cut-off points that distinguish symptoms of central sensitization at 12 weeks, using a retrospective prognostic cohort study design.
View Article and Find Full Text PDFInt J Environ Res Public Health
January 2025
Department of Psychology, Bowling Green State University, Bowling Green, OH 43403, USA.
Objective: Early childhood exposure to violent media content represents an actionable target for preventive intervention. The associated risks for later aggressive behavior have been established in childhood, but few studies have explored widespread long-term associations with antisocial behavior. We investigate prospective associations between exposure to violent television content in early childhood and subsequent antisocial behavior in mid-adolescence.
View Article and Find Full Text PDFNeuropharmacology
January 2025
Division of Molecular Psychiatry, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany; Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital Würzburg, Würzburg, Germany.
While healthy brain function relies on a dynamic but tightly regulated interaction between excitation (E) and inhibition (I), a spectrum of social cognition disorders, including antisocial behavior and antisocial personality disorder (ASPD), frequently ensuing from irregular neurodevelopment, may be associated with E/I imbalance and concomitant alterations in neural connectivity. Technological advances in the evaluation of structural and functional E/I balance proxies in clinical settings and in human cell culture models provide a general basis for identification of biomarkers providing a powerful concept for prevention and intervention across different dimensions of mental health and disease. In this perspective we outline a framework for research to characterize neurodevelopmental pathways to antisocial behavior and ASPD driven by (epi)genetic factors across life, and to identify molecular targets for preventing the detrimental effects of cognitive dysfunction and maladaptive social behavior, considering psychosocial experience; to validate signatures of E/I imbalance and altered myelination proxies as biomarkers of pathogenic neural circuitry mechanisms to determine etiological processes in the transition from mental health to antisocial behavior and ASPD and in the switch from prevention to treatment; to develop a neurobiologically-grounded integrative model of antisocial behavior and ASPD resultant of disrupted E/I balance, allowing to establish objective diagnoses and monitoring tools, to personalize prevention and therapeutic decisions, to predict treatment response, and thus counteract relapse; and finally, to promote transformation of dimensional disorder taxonomy and to enhance societal awareness and reception of the neurobiological basis of antisocial behavior and ASPD.
View Article and Find Full Text PDFPLoS Biol
January 2025
Department of Cell and Systems Biology, University of Toronto, Toronto, Canada.
Successful resolution of approach-avoidance conflict (AAC) is fundamentally important for survival, and its dysregulation is a hallmark of many neuropsychiatric disorders, and yet the underlying neural circuit mechanisms are not well elucidated. Converging human and animal research has implicated the anterior/ventral hippocampus (vHPC) as a key node in arbitrating AAC in a region-specific manner. In this study, we sought to target the vHPC CA1 projection pathway to the nucleus accumbens (NAc) to delineate its contribution to AAC decision-making, particularly in the arbitration of learned reward and punishment signals, as well as innate signals.
View Article and Find Full Text PDFNurs Rep
January 2025
Gregorio Marañón Health Research Institute (IiSGM), 28007 Madrid, Spain.
: Being a healthcare professional often involves exposure to complex situations that can contribute to the development of psychological problems. Evidence suggests that both mental and physical health are crucial for the well-being of these professionals, which in turn influences the quality of care they provide to patients. The main aim of this study was to examine the association between adaptive and maladaptive forms of humor and psychopathological disorders among healthcare workers.
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