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http://dx.doi.org/10.1016/j.omtn.2024.102430 | DOI Listing |
Mol Ther Nucleic Acids
March 2025
Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.
Mol Ther Nucleic Acids
September 2024
Department of Immuno-Oncology, Beckman Research Institute at City of Hope Comprehensive Cancer Center, Duarte, CA, USA.
Acute myeloid leukemia (AML) cells resist differentiation stimuli despite high expression of innate immune receptors, such as Toll-like receptor 9 (TLR9). We previously demonstrated that targeting Signal Transducer and Activator of Transcription 3 (STAT3) using TLR9-targeted decoy oligodeoxynucleotide (CpG-STAT3d) increases immunogenicity of human and mouse AML cells. Here, we elucidated molecular mechanisms of inv(16) AML reprogramming driven by STAT3-inhibition/TLR9-activation .
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