Unleashing the TLR9-driven multilineage differentiation of myeloid leukemia cells .

Mol Ther Nucleic Acids

Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland.

Published: March 2025

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754007PMC
http://dx.doi.org/10.1016/j.omtn.2024.102430DOI Listing

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Acute myeloid leukemia (AML) cells resist differentiation stimuli despite high expression of innate immune receptors, such as Toll-like receptor 9 (TLR9). We previously demonstrated that targeting Signal Transducer and Activator of Transcription 3 (STAT3) using TLR9-targeted decoy oligodeoxynucleotide (CpG-STAT3d) increases immunogenicity of human and mouse AML cells. Here, we elucidated molecular mechanisms of inv(16) AML reprogramming driven by STAT3-inhibition/TLR9-activation .

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