Objective: This study aimed to describe the anatomical landmarks for intervertebral disc (IVD) percutaneous approaches (transpedicular TPA and transannular TAA) using CT scans in humans and dogs for regenerative medicine research.
Method: CT scans of 57 human (30 supine, 27 prone) and 49 canine (29 chondrodystrophic, 20 non-chondrodystrophic) lumbar spines were analyzed. Morphometric data, cutaneous landmarks, and approach angles were measured, with additional sections assessing nerve root distances from TPA routes.
Results: Over 15,000 measurements were taken, creating a comprehensive anatomical database. Significant differences in TPA and TAA angles were noted between humans and dogs (p < 0.0001).
Conclusion: This study provides detailed anatomical landmarks for safe and effective IVD approaches, offering valuable guidance for translational research and surgical interventions.
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http://dx.doi.org/10.1016/j.ocarto.2024.100557 | DOI Listing |
Objective: Cervical degeneration involves many pathophysiological changes. Vertebral bone loss, sclerotic hyperplasia of the vertebral body and intervertebral disc degeneration (IDD) are most common degenerative factors. However, whether there is a correlation between changes in vertebral bone mass and IDD remains unclear.
View Article and Find Full Text PDFOsteoarthr Cartil Open
March 2025
Nantes Université, Oniris, CHU Nantes, INSERM, Regenerative Medicine and Skeleton, RMeS, UMR 1229, Nantes, F-44000, France.
Objective: This study aimed to describe the anatomical landmarks for intervertebral disc (IVD) percutaneous approaches (transpedicular TPA and transannular TAA) using CT scans in humans and dogs for regenerative medicine research.
Method: CT scans of 57 human (30 supine, 27 prone) and 49 canine (29 chondrodystrophic, 20 non-chondrodystrophic) lumbar spines were analyzed. Morphometric data, cutaneous landmarks, and approach angles were measured, with additional sections assessing nerve root distances from TPA routes.
World J Orthop
January 2025
Department of Orthopedics, The Third Medical Center, General Hospital of the Chinese People's Liberation Army, Beijing 100039, China.
Lumbar intervertebral disc degeneration is thought to be the main cause of low back pain, although the mechanisms by which it occurs and leads to pain remain unclear. In healthy adult discs, vessels and nerves are present only in the outer layer of the annulus fibrosus and in the bony endplate. Animal models, and histological and biomechanical studies have shown that annulus tear or endplate injury is the initiating factor for painful disc degeneration.
View Article and Find Full Text PDFWorld J Orthop
January 2025
Department of Orthopeadics, Featured Medical Center of Chinese People's Armed Police Forces, Tianjin 300000, China.
In healthy intervertebral discs (IVDs), nerves and blood vessels are present only in the outer annulus fibrosus, while in degenerative IVDs, a large amount of nerve and blood vessel tissue grows inward. Evidence supports that neurogenic inflammation produced by neuropeptides such as substance P and calcitonin gene related peptide released by the nociceptive nerve fibers innervating the IVDs plays a crucial role in the process of IVD degeneration. Recently, non-neuronal cells, including IVD cells and infiltrating immune cells, have emerged as important players in neurogenic inflammation.
View Article and Find Full Text PDFActa Radiol
January 2025
Department of Radiology, Zhongshan Hospital (Xiamen), Fudan University, Xiamen, PR China.
Background: Early detection of changes in lumbar intervertebral disc degeneration (IVDD) has great clinical significance. T1rho and UTE-T2* relaxometry are capable of providing information about biochemical changes in IVDD. However, they have not been previously analyzed and compared directly in the same patients.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!