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Genesis of concurrent diseases: do diabetes mellitus and idiopathic pulmonary fibrosis have a direct relationship?
Thorax
January 2025
Medicine, SUNY Downstate Medical Center, New York, New York, USA
Engineering Planar Crystallinity in Nitrogen-Vacancy-Incorporated Carbon Nitride for Efficient Photoredox Catalysis.
ACS Appl Mater Interfaces
January 2025
Key Laboratory of Functional Inorganic Material Chemistry, Ministry of Education of the People's Republic of China, School of Chemistry and Materials Science, Heilongjiang University, Harbin 150080, People's Republic of China.
The concurrent evolution of value-added benzimidazole compounds and hydrogen within the domain of chemical synthesis is of paramount importance. The utilization of photocatalysis enhances both the efficiency and environmental benignity of the synthetic process. However, it is profoundly challenging within a photocatalytic system to simultaneously augment the number of active sites and the internal transport rate of photogenerated charge carriers.
View Article and Find Full Text PDFAvoiding prostate bed radiation for the PSMA-PET detected nodal recurrence patient post prostatectomy.
Clin Transl Radiat Oncol
January 2025
Northern Sydney Cancer Centre, Radiation Oncology Unit, Royal North Shore Hospital, St Leonards, Sydney, NSW, Australia.
Background: Nodal only recurrence post radical prostatectomy (RP) is increasingly recognised in the PSMA scan era. Management is controversial with a curative approach usually incorporating prostate bed and nodal irradiation (PB + NRT) in combination with long-term hormonal therapy. It is unknown whether omitting prostate-bed irradiation (PBRT) is safe in a subgroup of these patients.
View Article and Find Full Text PDFNeoantigen architectures define immunogenicity and drive immune evasion of tumors with heterogenous neoantigen expression.
J Immunother Cancer
November 2024
Koch Institute for Integrative Cancer Research, Massachusetts Institute for Technology, Cambridge, Massachusetts, USA
Background: Intratumoral heterogeneity (ITH) and subclonal antigen expression blunt antitumor immunity and are associated with poor responses to immune-checkpoint blockade immunotherapy (ICB) in patients with cancer. The underlying mechanisms however thus far remained elusive, preventing the design of novel treatment approaches for patients with high ITH tumors.
Methods: We developed a mouse model of lung adenocarcinoma with defined expression of different neoantigens (NeoAg), enabling us to analyze how these impact antitumor T-cell immunity and to study underlying mechanisms.
Evaluating the Importance of Practice-level Factors on Adherence to Prostate Cancer Treatment Guidelines in Urology.
Urology
November 2024
Genesis Healthcare Partners, San Diego, CA.
Objective: To evaluate adherence to treatment guideline recommendations across the continuum of prostate cancer (PCa) care by US community urologists using several PCa-specific performance indicators (PIs). Additionally, to determine which practice-related factors, such as having a designated PCa patient champion, active patient management in a patient portal, and in-office dispensing of medications, were associated with improved PI performance.
Methods: Electronic medical record data were collected retrospectively from the PPS Analytics Patient Population Health Management Platform.
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