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Non-targeted metabolomic study in plasma in rats with post-traumatic osteoarthritis model.
PLoS One
March 2025
Department of Orthopaedics, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China.
Purpose: This study aimed to examine the differential expression profiles of plasma metabolites in rat models of post-traumatic osteoarthritis (PTOA) and elucidate the roles of metabolites and their pathways in the progression of PTOA using bioinformatics analysis.
Method: Plasma samples were collected from 24 SD female rats to model PTOA, and metabolomic assays were conducted. The samples were divided into three groups: the surgically induced mild PTOA group (Group A: 3 weeks postoperative using the modified Hulth model; age 2 months), the surgically induced severe PTOA group (Group B: 5 weeks postoperative using the modified Hulth model; age 2 months), and the normal control group (Group C: healthy rats aged 2 months).
PVR exposure influences the activation, adhesion, and protein expression of human CD8+ T cells, including the CD96-mediated transfer of PVR.
J Immunol
January 2025
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, United States.
Poliovirus receptor (PVR) ligands have gained attention as immunotherapy targets, yet their regulation remains unclear. Here, we examine the impact of PVR exposure on primary human CD8+ T cells. We used flow cytometry and Western blot analysis to quantify expression of PVR and its ligands in naïve and effector T cells and used adhesion assays and enzyme-linked immunosorbent assay (ELISA) to assess the impact of PVR on T cell adhesion and cytokine production.
View Article and Find Full Text PDFBurden of mild and moderate atopic dermatitis in adults: results from a real-world study in the United States.
Arch Dermatol Res
March 2025
HTA, Value and Evidence, Pfizer Inc, Groton, CT, USA.
Few studies explore the burden of mild-to-moderate atopic dermatitis (AD). We aimed to investigate disease burden in mild-to-moderate AD using real-world data from adults with AD and their physicians in the United States. Data were drawn from the Adelphi Real World AD Disease Specific Programme™, a cross-sectional survey of physicians and their patients with AD in real-world clinical practice in the US from November 2014 to February 2015.
View Article and Find Full Text PDFExercise-induced Activation of SIRT1/BDNF/mTORC1 Signaling Pathway: A Novel Mechanism to Reduce Neuroinflammation and Improve Post-stroke Depression.
Actas Esp Psiquiatr
March 2025
Graduate School, Harbin Sport University, 150008 Harbin, Heilongjiang, China; Department of Rehabilitation Medicine, The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, 150000 Harbin, Heilongjiang, China.
Background: Neuroinflammation and neurogenic disorders lead to depression in stroke patients. As, exercise intervention, a non-drug therapy, has been proven effective in post-stroke depression (PSD) patients. However, the underlying molecular mechanism by which exercise improves PSD still needs to be explored.
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