N-terminal acetyltransferase Naa50 plays an important regulatory role in ovule development by indirectly promoting cell wall invertase 2/4 expression.
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Naa50 regulates ovule and embryo sac development in Arabidopsis.
Plant Cell Rep
January 2025
College of Life Sciences, Shanxi Normal University, Taiyuan, 031002, Shanxi, China.
N-terminal acetyltransferase Naa50 plays an important regulatory role in ovule development by indirectly promoting cell wall invertase 2/4 expression.
View Article and Find Full Text PDFNα-acetyltransferase NAA50 mediates plant immunity independent of the Nα-acetyltransferase A complex.
Plant Physiol
July 2024
Centre for Organismal Studies, Heidelberg University, 69120 Heidelberg, Germany.
In humans and plants, 40% of the proteome is cotranslationally acetylated at the N-terminus by a single Nα-acetyltransferase (Nat) termed NatA. The core NatA complex is comprised of the catalytic subunit Nα-acetyltransferase 10 (NAA10) and the ribosome-anchoring subunit NAA15. The regulatory subunit Huntingtin Yeast Partner K (HYPK) and the acetyltransferase NAA50 join this complex in humans.
View Article and Find Full Text PDFThe regulation loop of MARVELD1 interacting with PARP1 in DNA damage response maintains genome stability and promotes therapy resistance of cancer cells.
Cell Death Differ
April 2023
School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
The DNA damage response (DDR) plays crucial roles in cancer prevention and therapy. Poly(ADP-ribose) polymerase 1 (PARP1) mediates multiple signal transduction in the DDR as a master regulator. Uncovering the regulatory factors of PARP1 contributes to a more comprehensive view of tumorigenesis and treatment strategies.
View Article and Find Full Text PDFPan-cancer analysis reveals NAA50 as a cancer prognosis and immune infiltration-related biomarker.
Front Genet
December 2022
Department of Thoracic Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.
N-Alpha-Acetyltransferase 50 (NAA50) has acetyltransferase activity and is important for chromosome segregation. However, the function and mechanism of NAA50 expression in cancer development was still unclear. Here, we systematically researched the function and mechanism of NAA50 in pan-cancer, and further verified the results of NAA50 in lung adenocarcinoma (LUAD).
View Article and Find Full Text PDFConstruction of the coexpression network involved in the pathogenesis of thyroid eye disease via bioinformatics analysis.
Hum Genomics
September 2022
Department of Endocrinology, HwaMei Hospital, University of Chinese Academy of Sciences, 41 Northwest Street Zhejiang Province, Ningbo, 315010, China.
Background: Thyroid eye disease (TED) is the most common orbital pathology that occurs in up to 50% of patients with Graves' disease. Herein, we aimed at discovering the possible hub genes and pathways involved in TED based on bioinformatical approaches.
Results: The GSE105149 and GSE58331 datasets were downloaded from the Gene Expression Omnibus (GEO) database and merged for identifying TED-associated modules by weighted gene coexpression network analysis (WGCNA) and local maximal quasi-clique merger (lmQCM) analysis.
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