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Background And Aims: The interaction of serum uric acid (SUA) with atherogenesis is incompletely understood. Aim of our study was to investigate the association of SUA levels with coronary plaque composition including high-risk-plaque (HRP) features by coronary computed tomography angiography (CTA) and for the prediction of major adverse cardiac events (MACE).

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Background: Preliminary research indicates that higher iron levels are associated with worse outcomes in patients with coronary artery disease.

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Coronary computed tomography angiography (CCTA) is a well-established and reliable non-invasive imaging modality that provides a comprehensive assessment of coronary artery anatomy and luminal stenosis due to atherosclerosis. Owing to advances in CCTA software and technology, the composition and morphology of coronary plaque can be accurately evaluated. Adverse features which identify plaque as being high-risk or 'vulnerable' can provide a personalised cardiovascular risk assessment over and above stenosis severity.

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Article Synopsis
  • The study investigates the connection between lipoprotein (a) [Lp(a)] levels and the risk of obstructive coronary artery disease (CAD) and high-risk plaque (HRP) in patients with stable chest pain.
  • Researchers analyzed data from the PROMISE Trial, finding that elevated Lp(a) (≥50 mg/100 ml) correlates with greater chances of having stenosis (≥50% and ≥70%) in coronary arteries, regardless of low-density lipoprotein cholesterol (LDL-C) levels.
  • However, elevated Lp(a) was not linked to the presence of high-risk plaque when accounting for obstructive CAD, suggesting its role in CAD risk is more significant than in plaque features.
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