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| http://dx.doi.org/10.1016/j.identj.2024.12.005 | DOI Listing |
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Economic returns on investing in early childhood development in Vietnam: a cost-benefit analysis.
BMC Health Serv Res
March 2025
School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Background: Economic evidence on the long-term benefits of investing in early childhood development is limited. This study aimed to estimate the potential long-term economic benefits of an early childhood development intervention 'Learning Clubs' in Vietnam.
Methods: We conducted a cost-benefit analysis to estimate the costs and benefits of the intervention compared to the standard of care from a limited societal perspective.
Use machine learning to predict treatment outcome of early childhood caries.
BMC Oral Health
March 2025
Department of Stomatology, School of Medicine, Xiamen University, Xiamen, China.
Background: Early childhood caries (ECC) is a major oral health problem among preschool children that can significantly influence children's quality of life. Machine learning can accurately predict the treatment outcome but its use in ECC management is limited. The aim of this study is to explore the application of machine learning in predicting the treatment outcome of ECC.
View Article and Find Full Text PDFClinical and molecular spectrum of TK2-deficiency: a large Brazilian cohort.
Sci Rep
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Department of Neurology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, Brazil.
Biallelic pathogenic variants at TK2 lead to a severe and progressive myopathy (TK2d). For a disease with unspecific clinical findings, and the possibility of a supplementation therapy that changes the natural history of the disease, highlighting clinical features that increase suspicion and accelerate diagnosis is essential. Clinical and genetic findings of 36 Brazilian patients with TK2d were identified and presented in this work.
View Article and Find Full Text PDFInterferon Response Gene Score in Juvenile Dermatomyositis Correlates Strongly with Disease Activity.
J Rheumatol
March 2025
B.M. Feldman, MD MSc FRCPC, Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario Canada; Department of Pediatrics, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Child Health Evaluative Sciences, SickKids Research Institute, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada; Institute of Health Policy Management & Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Objective: Type 1 interferons (IFNs) have been identified as potentially important measures of disease activity in Juvenile Dermatomyositis (JDM). An Interferon Response Gene-score (IRG-score) has been defined using NanoString technology and appears to correlate with disease activity in cross-sectional samples of JDM patients. This study aimed to determine if there is evidence of a correlation between disease activity and IRG-score, in patients with JDM, both early in disease course and longitudinally.
View Article and Find Full Text PDFThe sick child in art.
Arch Dis Child
March 2025
Department of Paediatrics University of Melbourne and Intensive Care Unit, Royal Children's Hospital, Parkville, Victoria, Australia
There are at least 12 paintings from the late 17th to the early 20th centuries titled, 'The Sick Child'. They were painted by well-known and obscure artists from Holland, Norway, France, England, Spain, North and South America. Most depict infants, and some older children, always in their homes, most with the mother at the bedside.
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