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Peripartum Mental Illness in Mothers With Multiple Sclerosis and Other Chronic Diseases in Ontario, Canada.
Neurology
February 2025
Schools of Pharmacy and Public Health Sciences, University of Waterloo, Ontario, Canada.
Background And Objectives: Peripartum mood and anxiety disorders constitute the most frequent form of maternal morbidity in the general population, but little is known about peripartum mental illness in mothers with multiple sclerosis (MS). We compared the incidence and prevalence of peripartum mental illness among mothers with MS, epilepsy, inflammatory bowel disease (IBD), and diabetes and women without these conditions.
Methods: Using linked population-based administrative health data from ON, Canada, we conducted a cohort study of mothers with MS, epilepsy, IBD, and diabetes and without these diseases (comparators) who had a live birth with index dates, defined as 1 year before conception, between 2002 and 2017.
Peripartum Mental Illness in Mothers With Multiple Sclerosis Merits Neurologists' Attention.
Neurology
February 2025
Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic, OH.
From Pregnancy to Postpartum: The Dynamic Reorganization of the Maternal Brain.
Neurosci Insights
January 2025
Department of Psychiatry, Psychotherapy and Psychosomatics, Faculty of Medicine, RWTH Aachen, Aachen, Germany.
The postpartum period is marked by radical changes in the maternal brain. Seeking to explore the mechanisms that underlie these changes, this article focuses on the relevant hormonal, inflammatory, and behavioral factors. Longitudinal imaging studies have shed valuable light on both short- and long-term alterations in postpartum brain structure and connectivity, particularly in the regions that play key roles in emotion regulation and stress response.
View Article and Find Full Text PDFManaging pre and postpartum mental health issues of refugee women from fragile and conflict-affected countries: A systematic review.
Public Health Pract (Oxf)
June 2025
Evidence Synthesis Ireland and Cochrane Ireland, University of Galway, Galway, Ireland.
Objective: Refugee or immigrant women residing in conflict prone countries portray elevated mental health related vulnerabilities during their peripartum periods and require effective interventions for improved maternal and child well-being. The objective of this systematic review is to generate evidence on effective interventions for managing peripartum mental health issues among refugee women from conflicted settings.
Study Design: Systematic review.
Combination of rTMS and oxytocin agonist attenuate depression-like behavior after postpartum depression in mice.
Brain Res
January 2025
Department of Orthopaedics of Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children's Health, Hangzhou, China. Electronic address:
The Diagnostic and Statistical Manual of Mental Disorders (DSM-5) categorizes postpartum depression (PPD) as a subtype of Major Depressive Disorder (MDD) with peripartum onset, generally arising within the initial trimester following delivery. This acute psychiatric condition is characterized by feelings of worthlessness, insomnia, extreme anxiety, or maternal neglect. Intranasal oxytocin (OT) and transcranial magnetic stimulation (TMS) have the potential to address impaired social cognition; nonetheless, their neuronal underpinnings, along with their safety and efficacy, are little comprehended.
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