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Azygos Vein Stenosis in Frontotemporal Dementia Sagging Brain Syndrome.
AJNR Am J Neuroradiol
January 2025
Ataxia Center, Cognitive Behavioral Neurology Unit, Laboratory for Neuroanatomy and Cerebellar Neurobiology, Department of Neurology (J.D.S., Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Background And Purpose: Symptoms indistinguishable from behavioral-variant frontotemporal dementia (bvFTD) can develop in patients with spontaneous intracranial hypotension associated with severe brain sagging. An underlying spinal CSF leak can be identified in only a minority of these patients and the success rate of nondirected treatments, such as epidural blood patching and dural reduction surgery, is low. The disability associated with bvFTD sagging brain syndrome is high and, because of the importance of the venous system in the pathophysiology of CSF leaks in general, we have investigated the systemic venous circulation in those patients with recalcitrant symptoms.
View Article and Find Full Text PDF[Brain sagging dementia-A rare potentially reversible cause of dementia].
Nervenarzt
January 2025
Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland.
Mild cognitive impairment in spontaneous intracranial hypotension and its rapid reversal by repair of a spinal cerebrospinal fluid leak.
Headache
December 2024
Department of Neurosurgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Article Synopsis
- Patients with spontaneous intracranial hypotension (SIH) often experience cognitive issues such as difficulties in concentration and memory, prompting the inclusion of cognitive tests in their evaluation.
- A study involving 18 patients with active spinal CSF leaks showed that many experienced mild cognitive impairment upon admission, but their cognitive scores significantly improved after surgical treatment of the leaks.
- The results support a possible link between cognitive dysfunction and spinal CSF loss, indicating that addressing spinal CSF leaks may help alleviate cognitive issues in these patients.
Skull defect - Frontotemporal dementia sagging brain syndrome.
Ann Clin Transl Neurol
January 2025
Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Objective: Frontotemporal dementia (FTD) sagging brain syndrome is a disabling condition. An underlying spinal Cerebrospinal fluid leak can be identified in only a minority of patients and the success rate of non-directed treatments is low. Some of these patients have a remote history of craniectomy/cranioplasty and we report a positive response to custom implant cranioplasty revision many years after their initial cranioplasty.
View Article and Find Full Text PDFMovement Disorders in Brain Sagging Syndrome Due To Spontaneous Intracranial Hypotension: A Review.
Tremor Other Hyperkinet Mov (N Y)
September 2024
Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, US.
Background: Spontaneous intracranial hypotension (SIH), a treatable condition that stems from spinal leakage of cerebrospinal fluid, usually presents with orthostatic headache, nausea, vomiting, dizziness, and tinnitus. A subset of patients, especially those with sagging of brain structures ("brain sagging syndrome"), develop several movement abnormalities. As SIH is treatable with epidural blood patch (EBP), movement disorders neurologists should be familiar with this syndrome.
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