Background Coronary artery bypass grafting (CABG) improves outcomes in patients with ischemic left ventricular (LV) dysfunction, but accurate patient selection remains critical. Late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) imaging aids in assessing myocardial viability, a key predictor of surgical outcomes. This study aimed to evaluate the impact of myocardial viability on postoperative outcomes in patients undergoing CABG. Methods This was a single-center prospective analysis of clinical outcomes in 37 patients with impaired LV function (mean ejection fraction: 35.59%); myocardial viability was assessed using LGE-CMR prior to CABG. Patient demographics, perioperative details, and short-term outcomes, including in-hospital mortality and recovery metrics, were analyzed. Results Patients exhibited high myocardial viability (mean: 88.16%), with an average of 2.35 non-viable segments. In-hospital mortality was 5.4% (n=2), and the mean hospital stay was six days. Patients with greater viability demonstrated better recovery and fewer complications. Multivessel coronary artery disease was prevalent (94.6%, n=35), with tailored graft configurations addressing individual anatomical and disease complexities. Conclusion LGE-CMR is a valuable tool for predicting outcomes in ischemic LV dysfunction. Myocardial viability strongly correlates with improved surgical recovery, highlighting the importance of integrating LGE-CMR into preoperative decision-making. Further studies are required to explore the long-term impact of myocardial viability on treatment outcomes and quality of life.
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http://dx.doi.org/10.7759/cureus.76198 | DOI Listing |
Cureus
December 2024
Cardiovascular Medicine, Hayatabad Medical Complex Peshawar, Peshawar, PAK.
Background Coronary artery bypass grafting (CABG) improves outcomes in patients with ischemic left ventricular (LV) dysfunction, but accurate patient selection remains critical. Late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) imaging aids in assessing myocardial viability, a key predictor of surgical outcomes. This study aimed to evaluate the impact of myocardial viability on postoperative outcomes in patients undergoing CABG.
View Article and Find Full Text PDFIn Vitro Cell Dev Biol Anim
January 2025
Department of Critical Care Medicine, The Qujing NO.1 People's Hospital, Qujing, 655000, Yunnan, China.
Melatonin (MEL), functioning as a circulating hormone, is important for the regulation of ferroptosis in different health scenarios and acts as a crucial antioxidant in cardiovascular diseases. However, its specific function in ferroptosis related to myocardial ischemia-reperfusion injury (MIRI) remains to be fully elucidated. In our research, we utilized a rat model of MIRI induced by coronary artery ligation, along with a cell model subjected to hypoxia/reoxygenation (H/R).
View Article and Find Full Text PDFOpen Life Sci
December 2024
Department of Cardiology, The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi), Zunyi, 563000, Guizhou, People's Republic of China.
We investigated the protective effect of the NF-κB inhibitor, pyrrolidine dithiocarbamate (PDTC) on cardiomyocyte injury induced by HCN1 channel overexpression, and explored the underlying mechanisms. An HCN1 overexpression vector was constructed and transfected into H9C2 cells, followed by PDTC treatment. The experiments comprised the following groups: control, control + PDTC, overexpression negative control, HCN1 overexpression (HCN1-OE), and combined HCN1-OE + PDTC groups.
View Article and Find Full Text PDFCell Biochem Biophys
January 2025
Department of Pharmacy, The Fourth Affiliated Hospital of Soochow University, Jiangsu, Suzhou, 215000, China.
Total glucosides of paeony (TGP) have been investigated for their effects on cardiomyocyte hypertrophy induced by angiotensin II (Ang II). In this study, rat cardiomyocyte H9c2 cells were treated with various doses of TGP (0, 12.5, 25, 50, 100, 200, and 400 μmol/L), and cell viability was assessed using the MTT method to determine an optimal dose.
View Article and Find Full Text PDFNan Fang Yi Ke Da Xue Xue Bao
January 2025
Department of Cardiovascular Diseases, First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, China.
Objectives: To investigate the mechanism through which N-acetylneuraminic acid (Neu5Ac) exacerbates hypoxia/reoxygenation (H/R) injury in rat cardiomyocytes (H9C2 cells).
Methods: H9C2 cells were cultured in hypoxia and glucose deprivation for 8 h followed by reoxygenation for different durations to determine the optimal reoxygenation time. Under the optimal H/R protocol, the cells were treated with 0, 5, 10, 20, 30, 40, 50, and 60 mmol/L Neu5Ac during reoxygenation to explore the optimal drug concentration.
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