The implementation of large-scale universal quantum computation represents a challenging and ambitious task on the road to quantum processing of information. In recent years, an intermediate approach has been pursued to demonstrate quantum computational advantage via non-universal computational models. A relevant example for photonic platforms has been provided by the Boson Sampling paradigm and its variants, which are known to be computationally hard while requiring at the same time only the manipulation of the generated photonic resources via linear optics and detection. Beside quantum computational advantage demonstrations, a promising direction towards possibly useful applications can be found in the field of quantum machine learning, considering the currently almost unexplored intermediate scenario between non-adaptive linear optics and universal photonic quantum computation. Here, we report the experimental implementation of quantum machine learning protocols by adding adaptivity via post-selection to a Boson Sampling platform based on universal programmable photonic circuits fabricated via femtosecond laser writing. Our experimental results demonstrate that Adaptive Boson Sampling is a viable route towards dimension-enhanced quantum machine learning with linear optical devices.
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http://dx.doi.org/10.1038/s41467-025-55877-z | DOI Listing |
Nat Commun
January 2025
Dipartimento di Fisica, Sapienza Università di Roma, Piazzale Aldo Moro 5, I-00185, Roma, Italy.
The implementation of large-scale universal quantum computation represents a challenging and ambitious task on the road to quantum processing of information. In recent years, an intermediate approach has been pursued to demonstrate quantum computational advantage via non-universal computational models. A relevant example for photonic platforms has been provided by the Boson Sampling paradigm and its variants, which are known to be computationally hard while requiring at the same time only the manipulation of the generated photonic resources via linear optics and detection.
View Article and Find Full Text PDFData Brief
February 2025
SCES, Strathmore University, Nairobi, Kenya.
Quantum Cascade Lasers (QCL) are promising semiconductor lasers, compact and powerful, but of complex design. Availability of structured data of the QCL properties can support data mining activities that seek to understand the relationship between these properties, for instance between the design and performance features. The main open source of QCL data is in scientific text which in most cases is usually unstructured.
View Article and Find Full Text PDFJ Chem Inf Model
January 2025
Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, People's Republic of China.
In recent decades, covalent inhibitors have emerged as a promising strategy for therapeutic development, leveraging their unique mechanism of forming covalent bonds with target proteins. This approach offers advantages such as prolonged drug efficacy, precise targeting, and the potential to overcome resistance. However, the inherent reactivity of covalent compounds presents significant challenges, leading to off-target effects and toxicities.
View Article and Find Full Text PDFJ Phys Chem Lett
January 2025
Institute for Molecular Modeling and Simulation, Department of Material Sciences and Process Engineering, University of Natural Resources and Life Sciences, Vienna, Muthgasse 18, Vienna 1190, Austria.
In the past decade, machine-learned potentials (MLP) have demonstrated the capability to predict various QM properties learned from a set of reference QM calculations. Accordingly, hybrid QM/MM simulations can be accelerated by replacement of expensive QM calculations with efficient MLP energy predictions. At the same time, alchemical free-energy perturbations (FEP) remain unachievable at the QM level of theory.
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