Mitochondria mechanosensing: The powerhouse fueling cellular force signaling.

Curr Biol

Institute for Bioengineering of Catalonia, The Barcelona Institute for Science and Technology, Barcelona, Spain; Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain. Electronic address:

Published: January 2025

Mechanical forces influence mitochondrial dynamics through previously unexplored mechanisms. A new study demonstrates that actomyosin tension inhibits mitochondrial fission by phosphorylating a key component of the fission complex and that this event regulates the nuclear accumulation of critical transcription factors.

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http://dx.doi.org/10.1016/j.cub.2024.12.006DOI Listing

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