Eukaryotic cells typically express multiple tubulin isoforms that form the microtubule cytoskeleton. A new study of the evolution and functional diversification of pools of tubulin isoforms suggests that these proteins are part of a co-evolving network that includes the extensive microtubule interactome.
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Microtubules: Decoding tubulin diversity with help from an amoeba.
Curr Biol
January 2025
Max Planck Institute for Infection Biology, Berlin, Germany; Berliner Hochschule für Technik, Berlin, Germany. Electronic address:
Eukaryotic cells typically express multiple tubulin isoforms that form the microtubule cytoskeleton. A new study of the evolution and functional diversification of pools of tubulin isoforms suggests that these proteins are part of a co-evolving network that includes the extensive microtubule interactome.
View Article and Find Full Text PDFMuscle and Metabolic Genes Are Differentially Expressed During Thermal Acclimation by the Brook Trout Myotome.
J Exp Zool A Ecol Integr Physiol
January 2025
Department of Biology, Widener University, Chester, Pennsylvania, USA.
Cold-water fishes, such as Brook trout (Salvelinus fontinalis), are being challenged by the consequences of climate change. The ability of these fish to acclimate to warmer environmental conditions is vital to their survival. Acclimation to warmer water may allow brook trout to reduce the metabolic costs of higher temperatures.
View Article and Find Full Text PDFTubulin-Binding Region Modulates Cholesterol-Triggered Aggregation of Tau Proteins.
J Neurochem
January 2025
Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, USA.
A hallmark of Alzheimer disease (AD) and tauopathies, severe neurodegenerative diseases, is the progressive aggregation of Tau, also known as microtubule-associated Tau protein. Full-length Tau, also known as 2N4R, contains two N-terminal inserts that bind to tubulin. This facilitates the self-assembly of tubulin simultaneously enhancing stability of cell microtubules.
View Article and Find Full Text PDFHit Identification and Functional Validation of Novel Dual Inhibitors of HDAC8 and Tubulin Identified by Combining Docking and Molecular Dynamics Simulations.
Antioxidants (Basel)
November 2024
Department of Health Sciences, University Magna Græcia, 88100 Catanzaro, Italy.
Chromatin organization, which is under the control of histone deacetylases (HDACs), is frequently deregulated in cancer cells. Amongst HDACs, HDAC8 plays an oncogenic role in different neoplasias by acting on both histone and non-histone substrates. Promising anti-cancer strategies have exploited dual-targeting drugs that inhibit both HDAC8 and tubulin.
View Article and Find Full Text PDFProtamine 2 deficiency results in Septin 12 abnormalities.
Front Cell Dev Biol
October 2024
Laboratory of Reproductive Biology, Institute of Biotechnology, Czech Academy of Sciences, BIOCEV, Vestec, Czechia.
There is a well-established link between abnormal sperm chromatin states and poor motility, however, how these two processes are interdependent is unknown. Here, we identified a possible mechanistic insight by showing that Protamine 2, a nuclear DNA packaging protein in sperm, directly interacts with cytoskeletal protein Septin 12, which is associated with sperm motility. Septin 12 has several isoforms, and we show, that in the sperm, the short one (Mw 36 kDa) is mis-localized, while two long isoforms (Mw 40 and 41 kDa) are unexpectedly lost in sperm chromatin-bound protein fractions.
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