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Will Xylocore be the magic ELIXIR for peritoneal dialysis?
Perit Dial Int
January 2025
Renal Physiology and Dialysis Group, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Rationale and design of ELIXIR, a randomized, controlled trial to evaluate efficacy and safety of XyloCore, a glucose-sparing solution for peritoneal dialysis.
Perit Dial Int
January 2025
Research and Development, Iperboreal Pharma, Pescara, Italy.
Peritoneal dialysis adoption and technique survival is affected by limitations related to peritoneal membrane longevity and metabolic alterations. Indeed, almost all peritoneal dialysis fluids exploit glucose as an osmotic agent that rapidly diffuses across the peritoneal membrane, potentially resulting in metabolic abnormalities such as hyperglycemia, hyperinsulinemia, obesity, and hyperlipidemia. Moreover, glucose-degradation products generated during heat sterilization, other than glucose itself, induce significant morphological and functional changes in the peritoneum leading to ultrafiltration failure.
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