An Activatable Chemiluminescent Self-Reporting Sulfur Dioxide Donor for Inflammatory Response and Regulation of Gaseous Vasodilation.

Sulfur dioxide (SO), being a novel gaseous signaling molecule, exhibits significant potential for application in the field of cardiovascular diseases. SO donors serve as crucial tools for the transportation and regulation of SO in vivo, facilitating the investigation of physiological roles associated with this molecule. However, the current therapeutic SO donors lack the capability to monitor the real-time release of SO, thereby hindering accurate assessment of their therapeutic efficacy and target localization. Herein, we present an activatable chemiluminescent self-reporting SO donor () that can be selectively activated by peroxynitrite (ONOO) to release SO and enable real-time visualization of the extent of release through chemiluminescent imaging. In vitro and cellular experiments demonstrate that exhibits high selectivity and signal-to-noise ratio toward ONOO and effectively facilitates the SO release process. Finally, successfully achieved the response to the mouse inflammatory model and relieved vasoconstriction in zebrafish by releasing SO stimulated by ONOO. The findings suggest that exhibits impressive attributes in the diagnosis and treatment of SO-related diseases, opening the gateway for developing low-background and high-sensitivity self-reporting SO donors.