Platypnea-orthodeoxia syndrome (POS) is a rare clinical condition characterized by dyspnea and hypoxemia during orthostatism, with relief in the supine position. The diagnosis of POS requires a high clinical suspicion, and its etiology stems from the admixture of venous blood, poor in oxygen, with arterial blood via a shunt. A patent foramen ovale (PFO) is the most commonly encountered anomaly at the root of POS.  Here, we present the case of a 67-year-old female patient where suspected POS led to the diagnosis of a PFO, which was the cause of an ischemic stroke.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743469PMC
http://dx.doi.org/10.7759/cureus.75970DOI Listing

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Platypnea-orthodeoxia syndrome (POS) is a rare clinical condition characterized by dyspnea and hypoxemia during orthostatism, with relief in the supine position. The diagnosis of POS requires a high clinical suspicion, and its etiology stems from the admixture of venous blood, poor in oxygen, with arterial blood via a shunt. A patent foramen ovale (PFO) is the most commonly encountered anomaly at the root of POS.

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A PFO Mediated Persistent Right-to-Left Shunt, a Worse Form of Platypnea-Orthodeoxia Syndrome.

Heart Lung Circ

January 2025

Section of Cardiology, University of Manitoba, Max Rady College of Medicine, Winnipeg, MB, Canada. Electronic address: https://www.twitter.com/KassMalek.

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[Platypnea-orthodeoxia syndrome in a patient with heart failure: A case report].

Rev Med Interne

December 2024

Service de pathologies cardiovasculaires, hôpital d'instruction des armées Laveran, 34, boulevard Laveran, CS 50004, 13384 Marseille, France.

Introduction: The platypnea orthodeoxia syndrome is a rare clinical entity combining positional dyspnea and arterial oxygen desaturation during the transition to orthostatism, reversible on return to decubitus. The most frequent etiology of this syndrome is the presence of a patent foramen ovale (PFO) responsible for a right-to-left intracardiac shunt, the severity of which results in significant functional disability and a risk of death from hypoxia.

Case Report: We report the case of a 93-year old patient on long-term oxygen, initially hospitalized for acute heart failure following a community-acquired urinary tract infection.

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Platypnea-orthodeoxia syndrome (POS) is characterized by dyspnea due to a marked fall in blood oxygen saturation while assuming standing or sitting positions. It is a rare condition with an unknown prevalence. The triggering role may remain unclear in a considerable number of patients.

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Article Synopsis
  • Platypnea orthodeoxia syndrome (POS) is a rare cause of low oxygen levels that requires careful clinical evaluation and collaboration among specialists for diagnosis.
  • An 86-year-old male presented to the ER with low oxygen saturation (84%) and did not improve with supplemental oxygen; however, his oxygen levels increased significantly when lying down.
  • Diagnosis was confirmed through echocardiography revealing a large patent foramen ovale (PFO) causing a right-to-left shunt; he was treated successfully, improving his oxygen levels and allowing him to go home without supplemental oxygen.*
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