In recent decades, organic electrosynthesis has emerged as a practical, sustainable, and efficient approach that facilitates valuable transformations in synthetic chemistry. Combining electrochemistry with transition-metal catalysis is a promising and rapidly growing methodology for effectively forming challenging C-C and C-heteroatom bonds in complex molecules in a sustainable manner. In this review, we summarize the recent advances in the combination of electrochemistry and copper catalysis for various organic transformations.
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http://dx.doi.org/10.3762/bjoc.21.9 | DOI Listing |
Chem Commun (Camb)
January 2025
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Stockholm, SE-10691, Sweden.
Herein, we present a highly efficient allylic substitution of carbonates with Grignard reagents using a reusable cellulose-supported nanocopper catalyst. This approach highlights the first instance of heterogeneous catalysis for the cross-coupling of allylic alcohol substrates with Grignard reagents. The method features high yields, excellent regioselectivity, and complete chirality transfer.
View Article and Find Full Text PDFRSC Adv
January 2025
School of Chemistry and Molecular Engineering, East China University of Science and Technology 130 Meilong Road Shanghai 200237 China.
The hydrogenation of carbon dioxide into profitable chemicals is a viable path toward achieving the objective of carbon neutrality. However, the typical approach for hydrogenation of CO heavily relies on thermally driven catalysis at high temperatures, which is not aligned with the goals of carbon neutrality. Thus, there is a critical need to explore new catalytic methods for the high-efficiency conversion of CO.
View Article and Find Full Text PDFBeilstein J Org Chem
January 2025
Dipartimento di Scienza e Alta Tecnologia, Università degli Studi dell'Insubria, Via Valleggio 9, 22100, Como, Italy.
This review reports the achievements in copper(II) triflate-catalyzed processes concerning the multicomponent reactions, applied to the synthesis of acyclic and cyclic compounds. In particular, for the heteropolycyclic systems mechanistic insights were outlined as well as cycloaddition and aza-Diels-Alder reactions were included. These strategies have gained attention due to their highly atom- and step-economy, one-step multi-bond forming, mild reaction conditions, low cost and easy handling.
View Article and Find Full Text PDFBeilstein J Org Chem
January 2025
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760, Korea.
In recent decades, organic electrosynthesis has emerged as a practical, sustainable, and efficient approach that facilitates valuable transformations in synthetic chemistry. Combining electrochemistry with transition-metal catalysis is a promising and rapidly growing methodology for effectively forming challenging C-C and C-heteroatom bonds in complex molecules in a sustainable manner. In this review, we summarize the recent advances in the combination of electrochemistry and copper catalysis for various organic transformations.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
CNRS/UCSD, Chemistry, University of California, San Diego, 5213 Pacific Hall,, Department of Chemistry, 92093-0343, La jolla, UNITED STATES.
N-Heterocyclic carbene (NHC) ligands possess the ability to stabilize metal-based nanomaterials for a broad range of applications. With respect to metal-hydride nanomaterials, however, carbenes are rare, which is surprising if one considers the importance of metal-hydride bonds across the chemical sciences. In this study, we introduce a bottom-up approach leveraging preexisting metal-metal m-center-n-electron (mc-ne) bonds to access a highly stable cyclic(alkyl)amino carbene (CAAC) copper-hydride nanocluster, [(CAAC)6Cu14H12][OTf]2 with superior stability compared to Stryker's reagent, a popular commercial phosphine-based copper hydride catalyst.
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