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The Exposome and Human Health.
Environ Sci Technol
January 2025
Yale University, New Haven, Connecticut 06520, United States.
The GeoTox Package: open-source software for connecting spatiotemporal exposure to individual and population-level risk.
Hum Genomics
January 2025
Predictive Toxicology Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, 530 Davis Dr, Durham, NC, 27713, USA.
Background: Comprehensive environmental risk characterization, encompassing physical, chemical, social, ecological, and lifestyle stressors, necessitates innovative approaches to handle the escalating complexity. This is especially true when considering individual and population-level diversity, where the myriad combinations of real-world exposures magnify the combinatoric challenges. The GeoTox framework offers a tractable solution by integrating geospatial exposure data from source-to-outcome in a series of modular, interconnected steps.
View Article and Find Full Text PDFParticulate matter 2.5 (PM) - associated cognitive impairment and morbidity in humans and animal models: a systematic review.
J Toxicol Environ Health B Crit Rev
January 2025
Department of Biochemistry, Cancer Biology, Neuroscience & Toxicology, School of Medicine, Meharry Medical College, Nashville, TN, USA.
Particulate matter with an aerodynamic diameter of less than 2.5 µm (PM) is one of the criteria air pollutants that (1) serve as an essential carrier of airborne toxicants arising from combustion-related events including emissions from industries, automobiles, and wildfires and (2) play an important role in transient to long-lasting cognitive dysfunction as well as several other neurological disorders. A systematic review was conducted to address differences in study design and various biochemical and molecular markers employed to elucidate neurological disorders in PM -exposed humans and animal models.
View Article and Find Full Text PDFExploring the potential of MRM-IDA-EPI method in mass spectrometry for exposomic analysis: a commentary.
Arch Toxicol
January 2025
Lautenberg Environmental Health Sciences Laboratory, Department of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Exposomics is a field that studies environmental exposures and their impact on human health. The MRM-IDA-EPI method, which combines targeted and untargeted mass spectrometry methods, is useful for identifying and quantifying biomarkers in various biological matrices. The method's accuracy and precision in forensic toxicological screening suggest potential applications for detecting low-level environmental exposures.
View Article and Find Full Text PDFEnvironmental maternal exposures and the risk of premature birth and intrauterine growth restriction: The Generation Gemelli study protocol of newborn exposome.
PLoS One
January 2025
University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy.
Background: The study of women exposures and child outcomes occurring in the first 1,000 days of life since conception enhances understanding of the relationships between environmental factors, epigenetic changes, and disease development, extending beyond childhood and spanning the entire lifespan. Generation Gemelli is a recently launched case-control study that enrolls mother-newborns pairs in one of the largest university hospitals in Italy, in order to examine the association between maternal environmental exposures and intrauterine growth restriction (IUGR) and the risk of premature birth. The study will also evaluate the association of maternal exposures and the health and growth of infants and children up to 24 months of age.
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