Background: Phthalate exposure has been hypothesized to influence cholesterol metabolism and gallstone pathogenesis, but previous studies are limited. We aimed to examine the associations between urinary phthalate metabolites and prevalence of gallstone disease in a nationally representative sample.
Methods: We analyzed data on 1,696 adults aged ≥ 30 years from the National Health and Nutrition Examination Survey (NHANES) 2017-2018. Gallstone disease was defined based on self-reported physician-diagnosis. Exposure was measured by urinary concentrations of 10 phthalate metabolites. Multivariable logistic regression model was to assess individual exposure-effect associations. Weighted quantile sum (WQS) regression, Quantile g-computation (Qgcomp) analysis and Bayesian kernel machine regression (BKMR) assessed metabolite mixtures in relation to gallstones.
Results: In the multivariable logistic regression model, compared to the lowest quartile (Q1) of urinary mono (2-ethyl-5-carboxypentyl) phthalate (MECPP), the highest quartile (Q4) was associated with an 82% increased risk of gallstone formation (OR: 1.82, 95% CI: 1.17, 2.85). Similarly, for mono(3-carboxypropyl) phthalate (MCPP), the risk increased by 78% in the Q4 group compared to Q1 (OR: 1.78, 95% CI: 1.02, 3.14). The WQS index exhibited a significant positive association with gallstone prevalence (OR: 1.37, 95%CI: 1.02, 1.84). In the Qgcomp model, four urinary phthalate metabolites, including MECPP, MCPP, mono benzyl phthalate (MBzP) and mono-carboxynonyl phthalate (MCNP), were positively associated with an increased risk of gallstones. BKMR identified exposure-response trends for MECPP, MCPP, and MBzP.
Conclusion: Higher urinary phthalate metabolite concentrations were associated with increased gallstone risk. These novel findings suggest phthalate exposure may contribute to lithogenic pathogenesis. Future prospective and mechanistic research is warranted.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1186/s12889-025-21417-z | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Urinary phthalate metabolites associated with increased prevalence of gallstone disease in U.S. adults: data from the NHANES study.
BMC Public Health
January 2025
The First Hospital of Jilin University, No.1 Xinmin Street, Changchun, 130012, China.
Background: Phthalate exposure has been hypothesized to influence cholesterol metabolism and gallstone pathogenesis, but previous studies are limited. We aimed to examine the associations between urinary phthalate metabolites and prevalence of gallstone disease in a nationally representative sample.
Methods: We analyzed data on 1,696 adults aged ≥ 30 years from the National Health and Nutrition Examination Survey (NHANES) 2017-2018.
Urinary odor molecules in the Otassha Study can distinguish patients with sarcopenia: A pilot study.
Geriatr Gerontol Int
January 2025
Faculty of Life Sciences, Kyoto Sangyo University, Kyoto, Japan.
Aim: To identify sarcopenia markers in urinary odor.
Methods: We performed solid-phase microextraction from the headspace and gas chromatography-mass spectrometry analysis of urinary volatile organic compounds (VOCs) in 71 healthy individuals and 68 patients diagnosed with sarcopenia according to the Asian Working Group on Sarcopenia 2019 criteria. The mass-to-charge ratios (m/z) of 10 VOCs with a significant difference in the total ion chromatogram of 220 VOCs detected in this study were compared by U-test.
Effect of Fasting Status on Association between Exposure to Phthalate and Phenolics, and Thyroid Hormones in Adult Women of Reproductive Age.
Environ Res
January 2025
Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea; Institute of Health and Environment, Seoul National University, Seoul, Republic of Korea. Electronic address:
Diet is one of the important exposure sources for many urinary chemicals that have been investigated in association studies for thyroid hormone outcomes. For these chemicals, the fasting status of the study population can substantially affect the results of urinary biomonitoring. Such variability presents challenges for cross-sectional association studies, particularly when the substances of concern have short excretion half-lives.
View Article and Find Full Text PDFAssociation of diethylhexyl phthalate exposure with serum thyroid hormone levels: a systematic review and meta-analysis.
Am J Transl Res
December 2024
Department of Genetics and Endocrinology, Chengdu Women's and Children's Center Hospital, School of Medicine, University of Electronic Science and Technology of China Chengdu, Sichuan, China.
Objective: Evidence suggests that diethylhexyl phthalate (DEHP) may disrupt thyroid hormone homeostasis by targeting multiple components of the hypothalamic-pituitary-thyroid (HPT) axis, potentially harming human health. However, the relationship between DEHP exposure and thyroid function remains debated. We performed a meta-analysis to clarify the association between DEHP exposure and thyroid function.
View Article and Find Full Text PDFAssociation Between Endocrine-Disrupting Chemicals Exposure and Attention-Deficit/Hyperactivity Disorder Symptoms in Children With Attention-Deficit/Hyperactivity Disorder.
Soa Chongsonyon Chongsin Uihak
January 2025
Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.
Objectives: This study investigated the relationship between exposure to endocrine-disrupting chemicals (EDCs), specifically phthalates, bisphenol A, bisphenol F, and bisphenol S, and the severity of attention-deficit/hyperactivity disorder (ADHD) symptoms using neuropsychological tests in children diagnosed with ADHD.
Methods: This study included 67 medication-naïve children with ADHD aged 6-16 years. The urinary concentrations of EDCs were measured, and ADHD symptom severity was evaluated using neuropsychological tests and clinical symptom scale measurements.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!