With the importance of time and cost in today's world, it is essential to solve problems in the best way possible. Optimization is a process used to achieve this goal and is applied in several areas, one of which is route planning. Route optimization minimizes the use of resources such as fuel, distance, and time. This study aims to optimize the traveler's route, allowing the traveler to save money on fuel and visit more tourist attractions by utilizing the time saved. For this purpose, an application is developed that presents the attractions in a chosen province and then finds the acceptable route between the selected attractions. According to the obtained visit order, the bus or buses that will provide the fastest transportation between both locations are presented. The route is determined with a genetic algorithm (GA), which is known as one of the most effective optimization algorithms. In order to select the most appropriate crossover operator of the genetic algorithm, the performances of seven methods, namely One Point Crossover (OX1), Two Point Crossover (OX2), Position Based Crossover (PBX), Order Based Crossover (OBX), Partially Mapped Crossover (PMX), Cycle Crossover (CX) and Inversion Crossover (IX) are tested on the real-world problem in Konya/Türkiye. In addition, parameter tuning is performed for the values of the algorithm's parameters such as population size, number of iterations, crossover rate, and mutation rate. As a result of the comparison, PBX is defined as the most suitable method for the problem. In addition, combinations of the four crossover methods (PMX, PBX, OX1, OX2) that obtained the best results according to the experimental analyses were compared. The comparison show that combinations of the PBX method are found to be the most suitable and the use of crossover techniques as ensemble is more effective than crossover techniques used separately. Furthermore, the best combination method named PBX + OX1 of GA was compared with ABC, ACO, SA, TSA, and PSO methods. This method is determined to find the maximum number of feasible solutions for a 14-stop real-world problem and it's the shortest route in all trials and handling them in fewer iterations.
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http://dx.doi.org/10.1038/s41598-025-86695-4 | DOI Listing |
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Anhui Provincial Center of Drug Clinical Evaluation, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, People's Republic of China.
Topiramate is an antiepileptic drug (AED) that is effective in treating various types of epilepsy. This study evaluated the bioequivalence and safety of two topiramate tablets in healthy Chinese subjects under fasting and fed conditions. We designed an open-label, randomized, single-dose, two-period, crossover trial protocol.
View Article and Find Full Text PDFJ Org Chem
January 2025
School of Pharmaceutical Science, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
We report a photoredox-catalyzed three-component sulfonaminoalkynylation of alkenes with -aminopyridine salts and potassium alkynyltrifluoroborate salts. This aminoalkylation reaction underwent a radial/polar crossover mechanism, which was distinguished from the previous reports. A variety of β-alkynylated sulfonamides were obtained in moderate to excellent yields.
View Article and Find Full Text PDFJ Clin Microbiol
January 2025
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA.
We hypothesized that bighorn sheep ewes with chronic nasal carriage are the source of infection that results in fatal lamb pneumonia. We tested this hypothesis in captive bighorn ewes at two study facilities over a 5-year period, by identifying carrier ewes and then comparing lamb fates in groups that did (exposed pens) or did not (non-exposed pens) include one or more carrier ewes. Most (23 of 30) lambs born in exposed pens, but none of 11 lambs born in non-exposed pens, contracted fatal pneumonia.
View Article and Find Full Text PDFJ Vet Intern Med
January 2025
Boehringer Ingelheim Pharma GmbH & Co., Ingelheim, Germany.
Background: Myxomatous mitral valve disease (MMVD) is frequently diagnosed in small breed dogs. Pimobendan oral solution has been developed to improve dosing accuracy in small and toy breed dogs.
Hypothesis/objectives: Demonstrate bioequivalence of pimobendan oral solution with pimobendan chewable tablets using a pharmacokinetic and a pharmacodynamic study in healthy purpose bred dogs.
Front Pharmacol
January 2025
Department of Anesthesiology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Introduction: We determined the median effective dose and 95% confidence interval (CI) of remimazolam required to inhibit laryngeal mask airway (LMA) insertion reactions combined with sufentanil 0.3 μg/kg in pediatric anesthesia.
Methods: Children scheduled to undergo elective laryngeal mask anesthesia were divided into the preschool (age: 3-6 years) and school-age (6-12 years) groups.
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