The symptoms of stroke jeopardize patients' health and increase the burden on society and caregivers. Although the traditional symptom cluster research paradigm can enhance management efficiency, it fails to provide targets for intervention, thereby hindering the development of patient-centered precision medicine. However, the symptom network paradigm, as a novel research approach, addresses the limitations of traditional symptom management by identifying core symptoms and determining intervention targets, thereby enhancing the efficiency and precision of symptom management. This study. aims to explore the symptom network and core symptoms of acute-phase stroke patients. A convenience sample of 505 stroke patients was selected for this study. Symptoms were assessed by the Stroke Symptom Experience Scale.Exploratory factor analysis was utilized to extract symptom clusters, and network analysis was conducted to construct the symptom network and characterize its nodes. In this study, four symptom clusters were extracted through exploratory factor analysis. Based on the results of node predictability(re) and node centrality such as strength centrality (rs), it was found that the symptoms of "No interest in surroundings" (rs = 1.299, re = 1.081), "Be disappointed about future" (rs = 0.922, re = 0.901), and "Unable to maintain body balance" (rs = 0.747, re = 0.744) had the highest centrality and predictability values, indicating their core positions within the symptom network. No interest in surroundings, Be disappointed about future, and Unable to maintain body balance are core symptoms in the symptom network. In the future, intervention methods for core symptoms can be constructed and validated for their intervention effects to further demonstrate the benefits of core symptoms.
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http://dx.doi.org/10.1038/s41598-024-84642-3 | DOI Listing |
Comput Methods Biomech Biomed Engin
January 2025
Department of Gastroenterolgy, The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, China.
The global rise in Crohn's Disease (CD) incidence has intensified diagnostic challenges. This study identified circadian rhythm-related biomarkers for CD using datasets from the GEO database. Differentially expressed genes underwent Weighted Gene Co-Expression Network Analysis, with 49 hub genes intersected from GeneCards data.
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January 2025
Department of Environmental Health, School of Public Health, Zhengzhou University, Zhengzhou, Henan, 450001, P. R. China.
This study aims to investigate the role of cuprotosis in fluorosis and identify potential targeted drugs for its treatment. The GSE70719 and GSE195920 datasets were merged using the inSilicoMerging package. DEGs between the exposure and control groups were found using R software.
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January 2025
Centre for Research Impact & Outcome-Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Chemotherapy resistance (CR) represents one of the most important barriers to effective oncological therapy and often leads to ineffective intervention and unfavorable clinical prognosis. Emerging studies have emphasized the vital significance of extracellular RNA (exRNA) in influencing CR. This thorough assessment intends to explore the multifaceted contributions of exRNA, such as exosomal RNA, microRNAs, long non-coding RNAs, and circular RNAs, to CR in cancer.
View Article and Find Full Text PDFElife
January 2025
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University & IDG/McGovern Institute for Brain Research, Beijing, China.
Speech comprehension involves the dynamic interplay of multiple cognitive processes, from basic sound perception, to linguistic encoding, and finally to complex semantic-conceptual interpretations. How the brain handles the diverse streams of information processing remains poorly understood. Applying Hidden Markov Modeling to fMRI data obtained during spoken narrative comprehension, we reveal that the whole brain networks predominantly oscillate within a tripartite latent state space.
View Article and Find Full Text PDFClin Transl Gastroenterol
January 2025
Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Background: Neutrophil-to-lymphocyte ratio (NLR) is a novel biomarker studied in several autoimmune diseases including inflammatory bowel diseases (IBD) in adults, but poorly characterized in pediatric IBD (pIBD). We aimed to primarily investigate the relationship between NLR and pIBD endoscopic disease severity. We also examined whether NLR predicted hospitalization, surgery, and therapy response by 52 weeks.
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