Background: Drowning is a serious and neglected public health threat, and prevention of drowning has a multisectoral nature and requires multidimensional research. Therefore, this study aimed to evaluate the spatio-temporal variation in fatal unintentional drowning rates among the Iranian population from 2005 to 2022.
Methods: In this repeated cross-sectional study, registry data were extracted from legal medicine organisations during 2005-2022. The mortality rate per 1 million population was calculated by gender and province. The joinpoint regression model was fitted to estimate average annual percentage changes and an annual percentage change in the drowning mortality rate. We used spatial scan statistics to detect high-risk clusters of drowning deaths at the provincial level.
Results: Over 17 years 19 547 people died due to unintentional drowning. The highest yearly drowning rate was 15.58 per 1 000 000, and men had the highest rates of death (25.91) compared with women (4.98) in 2019. The overall mortality rate has decreased from 18.69 in 2005 to 12.87 in 2022. In the spatio-temporal analysis, four statistically significant high-risk clusters were detected in the north, southeast and centre of Iran.
Conclusion: The overall mortality rate in 2022 decreased compared with the 17-year period. In the spatial analysis, several high-risk clusters were identified in different locations, which highlights the importance of targeted and more comprehensive interventions. It seems that the prevention of drowning requires the effective participation of all responsible organisations and risk reduction plans in the field of environmental and individual risk factors.
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http://dx.doi.org/10.1136/ip-2024-045356 | DOI Listing |
Am J Physiol Heart Circ Physiol
January 2025
Comenius University Bratislava, Faculty of Pharmacy, Department of Pharmacology and Toxicology, Bratislava, Slovakia.
Cholinesterase (ChE) inhibitors are under consideration to be used in the treatment of cardiovascular pathologies. A prerequisite to advancing ChE inhibitors into the clinic is their thorough characterization in the heart. The aim here was to provide a detailed analysis of cardiac ChE to understand their molecular composition, localization, and physiological functions.
View Article and Find Full Text PDFCancer Epidemiol Biomarkers Prev
January 2025
University of Kentucky, Lexington, KY, United States.
Background: Kentucky is within the top five leading states for breast mortality nationwide. This study investigates the association between neighborhood socioeconomic disadvantage and breast cancer outcomes, including surgical treatment, radiation therapy, chemotherapy, and survival, and how associations vary by race and ethnicity in Kentucky.
Methods: We conducted a retrospective cohort analysis using data from the Kentucky Cancer Registry (KCR) for breast cancer patients diagnosed between 2010 and 2017, with follow-up through December 31, 2022.
Acta Clin Belg
January 2025
Erzurum Regional Training and Research Hospital, Department of Emergency Medicine, Erzurum, Turkey.
Objectives: In this study, the capacity of End-tidal carbon dioxide (EtCO2) levels to predict the risk of major cardiovascular events (MACE) in patients diagnosed with acute coronary syndrome and the relationship between risk scoring systems (TIMI, GRACE, HEART) and EtCO2 values were examined.
Methods: EtCO2 values of the patients in the study were measured with a capnography device. Each patient's MACE status was recorded.
JAMA Netw Open
January 2025
Department of Surgery, University of Washington, Seattle.
Importance: Timely access to care is a key metric for health care systems and is particularly important in conditions that acutely worsen with delays in care, including surgical emergencies. However, the association between travel time to emergency care and risk for complex presentation is poorly understood.
Objective: To evaluate the impact of travel time on disease complexity at presentation among people with emergency general surgery conditions and to evaluate whether travel time was associated with clinical outcomes and measures of increased health resource utilization.
JAMA Netw Open
January 2025
Department of Medicine, Harvard Medical School, Boston, Massachusetts.
Importance: Disease characteristics of genetically mediated coronary artery disease (CAD) on coronary angiography and the association of genomic risk with outcomes after coronary angiography are not well understood.
Objective: To assess the angiographic characteristics and risk of post-coronary angiography outcomes of patients with genomic drivers of CAD: familial hypercholesterolemia (FH), high polygenic risk score (PRS), and clonal hematopoiesis of indeterminate potential (CHIP).
Design, Setting, And Participants: A retrospective cohort study of 3518 Mass General Brigham Biobank participants with genomic information who underwent coronary angiography was conducted between July 18, 2000, and August 1, 2023.
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