Physical principles and mechanisms of cell migration.

NPJ Biol Phys Mech

Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN USA.

Published: January 2025

Cell migration is critical in processes such as developmental biology, wound healing, immune response, and cancer invasion/metastasis. Understanding its regulation is essential for developing targeted therapies in regenerative medicine, cancer treatment and immune modulation. This review examines cell migration mechanisms, highlighting fundamental physical principles, key molecular components, and cellular behaviors, identifying existing gaps in current knowledge, and suggesting potential directions for future research.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11738987PMC
http://dx.doi.org/10.1038/s44341-024-00008-wDOI Listing

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