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The versatility of phenothiazines as an anticancer drug scaffold.
Future Med Chem
January 2025
Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh, India.
Fluorescent Macrocyclic Arenes: Synthesis and Applications.
Angew Chem Int Ed Engl
January 2025
Institute of Chemistry Chinese Academy of Sciences, CAS Key Laboratory of Molecular Recognition and Function, Zhongguancun North First Street 2, 100190, Beijing, CHINA.
Fluorescent macrocyclic arenes have attracted increasing interest in macrocyclic and supramolecular chemistry due to their exceptional photophysical properties and versatile applications. Classical macrocyclic arenes modified with fluorescent groups at the upper or bottom rims have long provided valuable platforms across various fields. Recently, a large number of novel fluorescent macrocyclic arenes directly composed of polycyclic aromatic or heteroaromatic building blocks including naphthalene, anthracene, tetraphenylethene, pyrene, fluorene, carbazole, acridan, phenothiazine, coumarin, triphenylamine, benzothiadiazole and so on, have been reported, and they have shown specific fluorescent property, and also exhibited broad applications in molecular recognition, sensing, bioimaging and functional materials.
View Article and Find Full Text PDFA Sensitive and Reusable Phenothiazine-Benzophenone Based Fluorescence Probe for Detecting Hypochlorite in Environmental and Biological Systems.
J Fluoresc
January 2025
Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore -14, Tamil Nadu, India.
This study addresses the critical issue of irreversible oxidation in hypochlorite (ClO⁻) sensing by a phenothiazine-based compound, which typically leads to the probe's degradation and loss of functionality. We introduce a novel fluorescence probe, (2-(5-(10 H-phenothiazin-10-yl)thiophen-2-yl)-1 H-benzo[d]imidazol-6-yl)(phenyl)methanone (PTH-BP), specifically designed to enhance ClO⁻ detection efficiency. PTH-BP exhibits strong aggregation-induced emission (AIE), emitting deep orange fluorescence at 620 nm with a large Stokes shift of 195 nm, and achieves an impressive detection limit of 1 nM in ACN/PBS buffer solutions.
View Article and Find Full Text PDFFerrocenyl Compounds as Alternative Redox Labels for Robust and Versatile Electrochemical Aptamer-Based Sensors.
ACS Sens
December 2024
Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Busan 46241, Korea.
Article Synopsis
- * One particular compound showed excellent performance with effective cross-linking, a stable electrochemical potential, and strong durability, making it ideal for sensor applications.
- * The compound demonstrated consistent current levels in serum, effectively detecting doxorubicin, thus indicating its potential for developing reliable and sensitive sensors in clinical settings.
Electrochemical Biosensor for the Assessment of Cell Viability Using Methylene Blue. Application to the Detection of Ciguatoxins in Fish from the Canary Islands.
Anal Chem
December 2024
IRTA, Marine and Continental Waters, Ctra. Poble Nou km 5.5, 43540 La Ràpita, Spain.
Cell-based biosensors (CBBs) for the detection of marine neurotoxins such as ciguatoxins (CTXs) are of high interest due to the composite toxicological response they can provide and the low limits of quantification (LOQs) they can achieve with the use of sensitive neural cells. However, the development and validation of CBBs are challenging due to the use of living material and the need for appropriate signal transduction strategies. In this work, Neuro-2a cells have been immobilized on thin-film gold electrodes, and their viability after exposure to CTX1B has been evaluated with light optical microscopy as well as cyclic voltammetry (CV) and differential pulse voltammetry (DPV) using methylene blue (MB) as a redox indicator.
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