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The Association Between Platelet Transfusion and Acute Kidney Injury Following Fontan Surgery.
World J Pediatr Congenit Heart Surg
March 2025
Section of Pediatric Critical Care, Hadassah University Medical Center, Jerusalem, Israel.
Previous studies have demonstrated an association between transfusion and increased organ dysfunction. We sought to determine the association between transfusion of blood components (red blood cell [RBC], plasma, platelet, and cryoprecipitate transfusions) with development of acute kidney injury (AKI) in children following the Fontan procedure. This is a single center, retrospective cohort study from 2009 to 2016.
View Article and Find Full Text PDFAltered leptin signaling and attenuated cardiac vagal activity in rats with type 2 diabetes.
Front Physiol
February 2025
Department of Emergency Medicine, University of Nebraska Medical Center, Omaha, NE, United States.
Introduction: The leading cause of death in type 2 diabetes mellitus (T2DM) patients is cardiovascular-related events, including myocardial infraction-induced ventricular arrhythmia. Previous studies have shown that T2DM-induced functional remodeling of cardiac vagal postganglionic (CVP) neurons contributes to ventricular arrhythmogenesis. As leptin resistance is common in T2DM patients, and CVP neurons are located in epicardial adipose pads, a tissue that secretes leptin, in this study we aimed to elucidate a correlation between leptin resistance and CVP neuronal dysfunction in T2DM.
View Article and Find Full Text PDFMicrocirculatory Dysfunction and Its Role in Diagnosing Acute Rejection in Pediatric Heart Transplantation: A Pilot Study.
Diagnostics (Basel)
February 2025
Hospital La Paz Institute for Health Research, IdiPAZ, 28046 Madrid, Spain.
: Acute rejection remains a major challenge in pediatric heart transplantation (HT), with limited tools for early diagnosis. In adult HT recipients, microcirculatory dysfunction, as measured by the index of microcirculatory resistance (IMR), has been identified as a potential biomarker of rejection. However, its role in pediatric populations is largely unexplored.
View Article and Find Full Text PDFHemodynamics during noninvasive ventilation in neonates.
Semin Perinatol
March 2025
Department of Pediatrics, Division of Neonatology, University of California, UC Davis Children's Hospital, Sacramento, USA.
Noninvasive ventilation (NIV) is increasingly used in neonatal care to reduce lung injury and improve respiratory outcomes. However, its effects on cardiovascular function and cardiopulmonary interactions, particularly in preterm neonates, remain unclear. This paper reviews the hemodynamic changes associated with NIV and provides an overview of how NIV influences cardiac preload, pulmonary vascular resistance, ventricular output, and systemic blood flow.
View Article and Find Full Text PDFHemodynamics of Veno-Pulmonary Extracorporeal Membrane Oxygenation With Varying Right Ventricular Function in a Mock Circulatory Loop.
ASAIO J
March 2025
Adult Intensive Care Service, The Prince Charles Hospital, Brisbane, Queensland, Australia.
Veno-pulmonary extracorporeal membrane oxygenation (VP ECMO) is an emerging mechanical support therapy for patients with right ventricular (RV) injury. This study aimed to assess the hemodynamic impact of VP ECMO using a mock circulatory loop (MCL) to simulate patients with varying levels of RV injury and pulmonary vascular resistance (PVR). Right ventricular injury was simulated by changing the end-systolic pressure-volume relationship (47.
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