Head lice infestation remains one of the most common child problems. This problem is not only attributed to the ability of head lice to spread rapidly but also because of the head lice resistance that develops from incomplete or improper treatment. Pyrethroids are a group of medications that have been widely used for the treatment of head lice. However, in recent years, several countries reported knockdown resistance (kdr). The aim of this study is to evaluate the frequency of pyrethroid-resistant mutations in Riyadh City, Saudi Arabia. To do that, Sanger sequencing was employed to find the frequency of mutated alleles in the voltage-sensitive sodium channel gene (VSSC). The result showed that the frequency of the resistant alleles in T917I was 0.83. In addition, three new mutations (L920F, V966F, and F967L) were detected in the examined samples. These findings highlight the significant prevalence of pyrethroid-resistant mutations, which may be attributed to the cultural and tourism openness that leads to the abundance of numerous job opportunities for different workforces from all around the world.
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Knockdown-resistant mutations in head lice (Pediculus humanus capitis) collected from schoolchildren in Riyadh, Saudi Arabia.
Sci Rep
January 2025
Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Head lice infestation remains one of the most common child problems. This problem is not only attributed to the ability of head lice to spread rapidly but also because of the head lice resistance that develops from incomplete or improper treatment. Pyrethroids are a group of medications that have been widely used for the treatment of head lice.
View Article and Find Full Text PDFFirst Report of the Gene Mutations Associated with Permethrin Resistance in Head Lice ( De Geer, 1767) from Primary School Children in Istanbul (Türkiye) and Nagarkot (Nepal).
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Department of Medical Microbiology, Acibadem University School of Medicine, Istanbul 34752, Türkiye.
Head lice infestation (HLI), caused by De Geer, 1767, has long been a common global problem of school children. Permethrin is an old pyrethroid derivative that has been used commonly for its treatment, and it exerts its activity over the voltage-sensitive calcium channels (VSCC) of the lice. There has been a growing list of persistent HLI cases lately in the world among patients using permethrin, and knockdown resistance (kdr)-related point mutations on VSCC have been identified and reported from those resistant lice samples.
View Article and Find Full Text PDFBartonella quintana Endocarditis Associated With Head Lice in a Canadian Indigenous Youth.
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From the Division of Infectious Diseases, Department of Paediatrics.
Bartonella quintana is a rare but important cause of culture-negative endocarditis, classically associated with body lice infestation. We report the first known pediatric case of Bartonella quintana endocarditis associated with head lice. The importance of sending targeted testing for this organism in at-risk patients, ideally on tissue specimens, is emphasized.
View Article and Find Full Text PDFArticle Synopsis
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