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A cost-effectiveness analysis of sotorasib as second-line treatment for patients with KRAS-G12C-mutated metastatic non-small cell lung cancer (mNSCLC) in Switzerland.
Swiss Med Wkly
January 2025
Cancer Center und Research Center, Cantonal Hospital Graubünden, Chur, Switzerland.
Background And Objective: Because of the lack of effective targeted treatment options, docetaxel has long been the standard second-line therapy for patients with advanced non-small cell lung cancer, including the Kirsten rat sarcoma virus (KRAS) G12C mutation. The CodeBreak 200 trial demonstrated that sotorasib, a new drug targeting the G12C-mutated KRAS protein, modestly improved progression-free survival compared with docetaxel in patients whose cancer had progressed after receiving platinum chemotherapy and programmed cell death protein 1 (PD-1) / programmed death ligand 1 (PD-L1) inhibitors as first-line treatment. Consequently, sotorasib received temporary approval in Switzerland.
View Article and Find Full Text PDFModeling the Health and Economic Impact of Pharmacologic Therapies for MASLD in the United States.
J Hepatol
January 2025
Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Background And Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common condition leading to chronic liver disease which generates substantial health care costs. Our aim was to model the impact on disease and economic burden of a hypothetical pharmacologic therapy which halts MASLD fibrosis progression.
Methods: The U.
A brief review on the progress of MXene-based catalysts for electro- and photochemical water splitting for hydrogen generation.
Chem Commun (Camb)
January 2025
Materials Genome Institute of Shanghai University, Shanghai 200444, China.
The development and generation of affordable and highly efficient energy, particularly hydrogen, are one of the best approaches to address the challenges posed by the depletion of non-renewable energy sources. Hydrogen energy, as a green and ecosystem-friendly source with zero carbon emission, can be generated through various methods, including water splitting (HER/OER) either photo- or electrocatalytic reactions. To implement these reactions effectively in practical applications, it is highly desirable to develop extremely efficient and cost-effective catalytic materials that are comparable to contemporary catalysts.
View Article and Find Full Text PDFA benchmarking study of individual somatic variant callers and voting-based ensembles for whole-exome sequencing.
Brief Bioinform
November 2024
Predictive Oncology Laboratory, Marseille Research Cancer Center, INSERM U1068, CNRS U7258, Institut Paoli-Calmettes, Aix-Marseille University, Equipe labellisée « Ligue Nationale Contre le Cancer », 13009 Marseille, France.
By identifying somatic mutations, whole-exome sequencing (WES) has become a technology of choice for the diagnosis and guiding treatment decisions in many cancers. Despite advances in the field of somatic variant detection and the emergence of sophisticated tools incorporating machine learning, accurately identifying somatic variants remains challenging. Each new somatic variant caller is often accompanied by claims of superior performance compared to predecessors.
View Article and Find Full Text PDFHow Should Clinicians Discuss Deprescribing with Caregivers of Older Adults Living with Dementia? A Qualitative Study.
Drugs Aging
January 2025
Division of Pharmaceutical Outcomes and Policy, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Background: Preventive medications are potential targets for deprescribing in older adults with dementia as goals of care change from preventive to palliative. Yet, prescribers lack communication guidance to address deprescribing.
Objective: Using bisphosphonates as a case example, we sought to characterize and compare communication preferences of prescribers and family/informal caregivers regarding deprescribing.
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