Introduction: Randomised controlled trials (RCTs) with surgical interventions frequently lack a framework to ensure surgical quality. We aimed to investigate surgical quality assurance (SQA) in oesophagogastric oncology trials and to develop a translatable framework of strategies to overcome challenges in the design and implementation of SQA.
Methods: Seventy-one peer-nominated, international, expert trial stakeholders included surgeons; oncologists; trial managers and trial methodologists. Semi-structured interviews were conducted with expert stakeholders examining challenges to SQA in oncology trials followed by a Delphi process to gain consensus on mitigating strategies. Relevant expert consensus strategies were selected for inclusion within a separate written survey and Delphi process in the active ADDICT RCT.
Results: Expert consensus was reached for 59 strategies to overcome challenges to SQA in oncology trials. 19 of these strategies were selected for inclusion within the ADDICT survey and Delphi process, of which 14 (74 %) gained consensus amongst ADDICT trial stakeholders across two Delphi rounds, indicating their relevance within an active surgical oncology RCT. Prominent mitigating strategies included operative monitoring using photographs and/or videos with a structured objective assessment tool. Summarising the expert Delphi consensus allowed formulation of a framework of strategies to overcome challenges to SQA in oncology trials (SQA-Onc.) CONCLUSION: In this first international expert consensus within this area, agreement was reached for 59 strategies to overcome challenges to implementation of SQA. The proposed SQA-Onc. tool is intended to support SQA measures within future trials. Validating this framework within the next generation of RCTs should be the focus of future research.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ejso.2025.109593 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Discovery of noncovalent diaminopyrimidine-based Inhibitors for glioblastoma via a dual FAK/DNA targeting strategy.
Eur J Med Chem
January 2025
School of Pharmaceutical Sciences, Guizhou University, Guiyang, 550025, China. Electronic address:
Temozolomide, a widely used alkylating agent for glioblastoma treatment, faces significant challenges due to the development of resistance, which severely impacts patient survival. This underscores the urgent need for novel strategies to overcome this barrier. Focal adhesion kinase (FAK), an intracellular non-receptor tyrosine kinase, is highly expressed in glioblastoma cells and has been identified as a promising therapeutic target for anti-glioblastoma drug development.
View Article and Find Full Text PDFProteomic characterization and comparison of the infective and adult life stage secretomes from Necator americanus and Ancylostoma ceylanicum.
PLoS Negl Trop Dis
January 2025
Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Australia.
More than 470 million people globally are infected with the hookworms Ancylostoma ceylanicum and Necator americanus, resulting in an annual loss of 2.1 to 4 million disability-adjusted-life-years. Current infection management approaches are limited by modest drug efficacy, the costs associated with frequent mass drug administration campaigns, and the risk of reinfection and burgeoning drug resistance.
View Article and Find Full Text PDFEnvironmental Challenges and Co-Infection Modulate Resistance and Tolerance Against Trypanosoma Cruzi and Trichinella Spiralis in Rats.
J Exp Zool A Ecol Integr Physiol
January 2025
Laboratorio de Ecología de Enfermedades, Instituto de Ciencias Veterinarias del Litoral (ICIVET LITORAL), Universidad Nacional del Litoral - CONICET, Santa Fe, Santa Fe, Argentina.
To overcome infection, hosts employ two defense strategies: resistance (which limits pathogen fitness), and tolerance (which reduces infection damage). These strategies may be influenced by environmental challenges such as food shortage, social conflict, and co-infections. Here, our objective was to assess defense strategies in rats infected with Trichinella spiralis and/or Trypanosoma cruzi under environmental challenges.
View Article and Find Full Text PDFGlycation-mediated pea protein isolate-curcumin conjugates for uniform walnut oil dispersion: enhancing oxidative stability and shelf life.
J Sci Food Agric
January 2025
SKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing, Liaoning Province Key Laboratory for Marine Food Science and Technology, School of Food Science and Technology, Dalian Polytechnic University, Dalian, China.
Background: Traditional methods for fabricating protein-polyphenol conjugates have not preserved the structural and functional integrity essential for the food industry effectively. This research introduces an advanced encapsulation methodology designed to overcome these limitations, with the potential to enhance the stability of edible oil matrices significantly, leading to improved preservation techniques and extended shelf life.
Results: Glycated pea protein isolate-curcumin conjugates (gPPI-CUR) were developed, demonstrating a marked improvement in the oxidative stability of walnut oil (WO), a proxy for edible oil matrices.
'Splice-at-will' Cas12a crRNA engineering enabled direct quantification of ultrashort RNAs.
Nucleic Acids Res
January 2025
Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province, School of Chemistry & Chemical Engineering, Shaanxi Normal University, 620 West Chang'an Avenue, Chang'an District, Xi'an, Shaanxi 710119, P.R. China.
We present a robust 'splice-at-will' CRISPR RNA (crRNA) engineering mechanism that overcomes the limitations of clustered regularly interspaced short palindromic repeats (CRISPR)/Cas system in directly detecting ultrashort RNAs. In this strategy, an intact Cas12a crRNA can be split from almost any site of the spacer region to obtain a truncated crRNA (tcrRNA) that cannot activate Cas12a even after binding an auxiliary DNA activator. While splicing tcrRNAs with a moiety of ultrashort RNA, the formed combination can work together to activate Cas12a efficiently, enabling 'splice-at-will' crRNA engineering.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!