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High HOMA2-B: A novel risk factor for diabetic peripheral neuropathy beyond metabolic syndrome components in type 2 diabetes.
J Diabetes Investig
January 2025
Laboratory of Medicine, Aichi Gakuin University School of Pharmacy, Nagoya, Aichi, Japan.
Elevated risk of infection in individuals with hyperinsulinaemic type 2 diabetes: a Danish 12 year cohort study.
Diabetologia
December 2024
Department of Clinical Epidemiology, Aarhus University Hospital and Aarhus University, Aarhus, Denmark.
Aims/hypothesis: A better understanding of the mechanisms underlying an elevated infection risk in individuals with type 2 diabetes is needed to guide risk stratification and prevention. We investigated the risk of infection in subgroups of individuals with type 2 diabetes according to indices of insulin sensitivity and beta cell function.
Methods: We classified 7265 individuals with recently diagnosed type 2 diabetes (median duration 1.
Associations of physiologic subtypes based on HOMA2 indices of β-cell function and insulin sensitivity with the risk of kidney function decline, cardiovascular disease, and all-cause mortality from the 4C study.
Cardiovasc Diabetol
November 2024
Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, Hubei, China.
Background: Previous studies have been limited by their inability to differentiate between the effects of insulin sensitivity and β-cell function on the risk of kidney function decline, cardiovascular disease (CVD), and all-cause mortality. To address this knowledge gap, we aimed to investigate whether the physiological subtypes based on homeostasis model assessment-2 (HOMA2) indices of β-cell function (HOMA2-B) and insulin sensitivity (HOMA2-S) could be used to identify individuals with subsequently high or low of clinical outcome risk.
Methods: This retrospective cohort study included 7,317 participants with a follow-up of up to 5 years.
Early impaired insulin tolerance among Vietnamese diabetes with or without dyslipidemia.
Medicine (Baltimore)
November 2024
Department of Pathophysiology, Vietnam Military Medical University, Hanoi, Vietnam.
This study aims to evaluate impaired insulin tolerance among Vietnamese diabetes with or without dyslipidemia. Diabetes mellitus (DM) remains the serious global health and social burden that has increased over the past few decades. It progresses silently to vascular injury and disability of injured vascular-perfused tissues/organs.
View Article and Find Full Text PDFComparison of clustering and phenotyping approaches for subclassification of type 2 diabetes and its association with remission in Indian population.
Sci Rep
August 2024
Government Yoga and Naturopathy Medical College & Hospital, Arumbakkam, Chennai, Tamilnadu, 600106, India.
Article Synopsis
- The study explores two methods for classifying type 2 diabetes (T2D) - clustering and subphenotyping - to identify subgroups in an Indian population and their remission rates.
- Three clusters emerged: severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD), and mild obesity-related diabetes (MOD), while four categories were identified in subphenotyping.
- The findings suggest that clustering may be more effective for T2D classification, particularly for individuals with high insulin sensitivity and beta-cell function, which is linked to better remission rates after a one-year intervention.
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