Background: The lacking proper regulation of International Normalized Ratio (INR) as the main problem in patients with mechanical valve replacement surgery poses the risk of thrombosis and embolism on the one hand and the risk of bleeding on the other. For this reason, the correct monitoring of INR via the Time in Therapeutic Range (TTR) is needed. The present study aimed to explore the blood coagulation monitoring of patients with mechanical heart valve in Imam Ali Hospital of Kermanshah in 2021.
Method: In the present cross-sectional study, the research population consisted of 139 patients, who underwent mechanical heart valve replacement. Information on patients' demographic variables, health records, comorbidities, and medications was collected using a checklist. During the monthly follow-up, INR and thrombotic and bleeding events were recorded through calls made to patients. Then the TTR was estimated based on Rosendahl's model and compared with the standard rate to test the relationship with hemorrhagic and thrombotic events in SPSS21.
Results: The mean and standard deviation of patients' age was 58.25 ± 10.16 years. Among 139 patients with mechanical heart valves, 55 (39.6%) were male and 84 (60.4%) were female. Ninety-one patients (65.5%) had primary-school education, 22 (15.8%) middle school education, 17 (12.2%) high school education and 9 (6.5%) had a university degree. Chi-square test results showed a positive and significant difference between the blood coagulation monitoring of patients with mechanical heart valves and sex, education, blood pressure, captopril drug and the number of visits and follow-up (p ≥ 0.05).
Conclusion: The present study showed that TTR was lower than normal in the target population. Therefore, it is necessary to closely monitor patients' blood coagulation for the appropriate therapeutic dose according to patients' sex, education, blood pressure, captopril drug and the number of visits and follow-up.
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| http://dx.doi.org/10.1186/s13019-024-03188-7 | DOI Listing |
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