Background: Climate-related health impacts have been a global public health concern. Identifying vulnerable populations is critical in implementing adaptation strategies. This study aimed to examine how heat-related impacts on all-cause emergency hospitalisations differ by area deprivation and urbanicity.
Methods: All-cause emergency hospitalisations were identified in the Japanese nationwide administrative database during the warm season between 2011 and 2019. A time-stratified case-crossover study was conducted to examine short-term associations between daily mean temperature and hospitalisation. Days of heat exposure were defined as days when the daily mean temperature exceeded the minimum morbidity temperature (ie, temperature with the lowest relative risk between the 25th and the 75th percentiles of the daily mean temperature distribution). Analyses were stratified by area deprivation index and urbanicity. Heat-related excess hospitalisations were quantified using the population attributable fraction (PAF), derived as a fraction of heat-attributable emergency hospitalisations to the total number of emergency hospitalisations for all study subjects or within specific subgroups.
Results: We identified 5 914 084 hospitalisations. Among all study subjects, PAF for heat-related excess hospitalisations was 1.69% (95% CI 1.54% to 1.87%). PAF for heat-related excess hospitalisations was more pronounced in people living in the most deprived areas (1.87%, 95% CI 1.68% to 2.06%) than those in the least deprived (1.19%, 95% CI 0.98% to 1.41%) and in urban populations (2.03%, 95% CI 1.78% to 2.30%) than rural ones (1.42% (95%CI 1.24% to 1.60%)). When further stratified by deprivation and urbanicity simultaneously, PAF for heat-related excess hospitalisations was most significant among urban populations living in the most deprived areas (2.62%, 95% CI 2.26% to 3.03%).
Conclusion: These findings revealed that individuals living in the most deprived areas in urban settings were particularly vulnerable to heat exposure. Adaptation strategies tailored to socioeconomic and geographical inequalities can potentially reduce future heat-related health impacts.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1136/jech-2024-222868 | DOI Listing |
Endocrinol Diabetes Metab
January 2025
Department of Endocrinology and Metabolism, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Objective: This study investigates the relationship between the albumin-to-creatinine ratio and diabetic retinopathy (DR) in US adults using NHANES data from 2009 to 2016. This study assesses the predictive efficacy of the urinary serum albumin-to-creatinine ratio (UACR/SACR Ratio) against traditional biomarkers such as the serum albumin-to-creatinine ratio (SACR) and urinary albumin-to-creatinine ratio (UACR) for evaluating DR risk. Additionally, the study explores the potential of these biomarkers, both individually and in combination with HbA1c, for early detection and risk stratification of DR.
View Article and Find Full Text PDFBioDrugs
January 2025
Orsay-Vallée Campus, Paris-Saclay University, Gif-sur-Yvette, France.
Liver cancer poses a global health challenge with limited therapeutic options. Notably, the limited success of current therapies in patients with primary liver cancers (PLCs) may be attributed to the high heterogeneity of both hepatocellular carcinoma (HCCs) and intrahepatic cholangiocarcinoma (iCCAs). This heterogeneity evolves over time as tumor-initiating stem cells, or cancer stem cells (CSCs), undergo (epi)genetic alterations or encounter microenvironmental changes within the tumor microenvironment.
View Article and Find Full Text PDFDiscov Oncol
January 2025
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Introduction: Colorectal cancer (CRC) is the second most common cause of cancer-related deaths globally. The gut microbiota, along with adenomatous polyps (AP), has emerged as a plausible contributor to CRC progression. This study aimed to scrutinize the impact of the FadA antigen derived from Fusobacterium nucleatum on the expression levels of the ANXA2 ceRNA network and assess its relevance to CRC advancement.
View Article and Find Full Text PDFIndian J Pediatr
January 2025
Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, India.
Objectives: To evaluate the predictive ability of furosemide stress test (FST), serum and urine cystatin-C in identifying progressive acute kidney injury (AKI) and the need for kidney replacement therapy (KRT).
Methods: Children aged one month to 18 y admitted in the pediatric intensive care unit (PICU) with Kidney Diseases Improving Global Outcomes (KDIGO) stage-1/2 AKI were enrolled. FST and serum and urine cystatin-C levels were performed and analyzed.
J Neuroimmune Pharmacol
January 2025
Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, PR China.
Emerging evidence highlights the significance of peripheral inflammation in the pathogenesis of Parkinson's disease (PD) and suggests the gut as a viable therapeutic target. This study aimed to explore the neuroprotective effects of the probiotic formulation VSL#3 and its underlying mechanism in a PD mouse model induced by MPTP. Following MPTP administration, the striatal levels of dopamine and its metabolites, as along with the survival rate of dopaminergic neurons in the substantia nigra, were significantly reduced in PD mice.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!