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Yak milk is a potential nutrient for improving osteoporosis. However, the effect of yak milk on the expression of Caion channel TRPV5 during osteoclast (OC) differentiation is still unclear. This study used ruthenium red as a control to investigate the effect of yak milk on osteoclast differentiation and activity. TRAP staining and bone resorption pit experiments showed that yak milk inhibited osteoclast differentiation and bone resorption activity in a dose-dependent manner. In addition, yak milk can inhibit osteoclast activity by inhibiting the expression of TRPV5. Quantitative Real-Time PCR and Western blot results also exhibited that yak milk significantly decreased the expression of TRPV5 and calbindin-D mRNA and protein in osteoclasts. These results suggest that yak milk inhibits RANKL-induced osteoclast differentiation and bone resorption activity in RAW264.7 cells by suppressing the expression level of TRPV5 and calbindin-D mRNA and protein.
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| http://dx.doi.org/10.3168/jds.2024-25607 | DOI Listing |
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