Flavonoid-rich extract of Paederia scandens (Lour.) Merrill improves hyperuricemia by regulating uric acid metabolism and gut microbiota.

Paederia scandens (Lour.) Merrill flavonoid-rich extract (PSMF) has shown excellent xanthine oxidase (XOD) inhibitory activity in our previous study. However, the efficacy of PSMF in mitigating hyperuricemia (HUA) remains to be elucidated. In this study, we investigated the effects and mechanisms of PSMF on alleviating in HUA mice. The results showed that PSMF intervention reduced serum levels of uric acid (UA), creatinine (CRE), and blood urea nitrogen (BUN), and inhibited the activities of XOD and adenosine deaminase (ADA). In addition, PSMF treatment not only attenuated the inflammatory response and renal damage but also regulated the expression of UA synthesis genes and UA excretion genes. Finally, PSMF ameliorated gut microbiota dysbiosis in HUA mice by enriching the abundance of short-chain fatty acid (SCFA)-producing bacteria. In summary, PSMF appears to be a promising natural source for the prevention and treatment of HUA.