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The involvement of endogenous melatonin in LPS-induced M1-like macrophages and its underlying synthesis mechanism regulated by IRF3.
Exp Cell Res
November 2024
School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China; Key Laboratory of Gastrointestinal Cancer (Fujian Medical University), Ministry of Education, Fuzhou, China. Electronic address:
Article Synopsis
- * The study found that the lipopolysaccharide (LPS) treatment, which normally promotes M1 polarization, actually increases endogenous MLT secretion in macrophages, indicating a possible protective mechanism.
- * Results show that LPS activates the TLR4/TRIF pathway leading to MLT secretion, with MLT helping to inhibit M1 polarization and reduce apoptosis in macrophages, highlighting its role in immune response and pathogen clearance.
Psychedelic research at a crossroads.
Science
September 2024
Alan K. Davis is an associate professor and director at the Center for Psychedelic Drug Research and Education, College of Social Work, The Ohio State University, Columbus, OH, USA and an adjunct professor at the Center for Psychedelic and Consciousness Research, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA. davis.
There is an urgent need to develop better treatments for mental health conditions that affect one in every eight people in the world. To combat this concern, psychedelic drugs have been combined with psychotherapy and studied in clinical trials in the United States and Europe. Psychedelics are hallucinogenic drugs that alter brain activity and facilitate altered states of consciousness.
View Article and Find Full Text PDFRetraction notice to "ICG fluorescence imaging technology in laparoscopic liver resection for primary liver cancer: A meta-analysis" [ 20(9) (2023) 15918-15941].
Math Biosci Eng
July 2024
P.O. Box 2604 Springfield, MO 65801-2604, USA.
Modeling mechanisms of chemotherapy-induced peripheral neuropathy and chemotherapy transport using induced pluripotent stem cell-derived sensory neurons.
Neuropharmacology
November 2024
Clinical Pharmacology, Pharmacy, and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark; Department of Clinical Pharmacology, Odense University Hospital, Odense, Denmark. Electronic address:
Background: and Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) constitutes a significant health problem due to the increasing prevalence and lack of therapies for treatment and prevention. While pivotal for routine cancer treatment, paclitaxel and vincristine frequently cause CIPN and impact the quality of life among cancer patients and survivors. Here, we investigate molecular mechanisms and drug transport in CIPN.
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