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- * Skin biopsies confirmed both nephrogenic systemic fibrosis and calciphylaxis, despite the patient never having been exposed to gadolinium-based contrast agents.
- * Despite receiving treatment that included daily dialysis and sodium thiosulfate, he rapidly deteriorated and passed away within two weeks due to complications from hospital-acquired pneumonia.
Common Histological Features Suggesting Enchondral Ossification Pathways in Calciphylaxis of Various Origins: A Study of Human Subcutaneous Tissue Biopsies.
Acta Derm Venereol
July 2023
Department of Internal Medicine I, Paracelsus Medical University, Salzburg, Austria.
Calciphylaxis is a rare, yet underdiagnosed condition causing high mortality in patients with severe renal and cardiovascular disease. Since knowledge of the pathophysiology of calciphylaxis is limited, a differential analysis of histological alterations in patient subgroups with various comorbidities might expose different disease phenotypes and allow deeper insights into the pathophysiology of the condition. Histological markers of osteogenesis and calcification were investigated in a group of 18 patients with clinically and histologically verified calciphylaxis, using immunohistochemical staining.
View Article and Find Full Text PDFThe Multifactorial Pathogenesis of Calciphylaxis: A Case Report.
Am J Case Rep
June 2021
Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, Szczecin, Poland.
BACKGROUND Calciphylaxis is a rare and lifethreatening syndrome characterized by small vascular calcifications, which lead to the occlusion of blood vessels and painful skin lesions with tissue necrosis. Although the disease can develop in a population without kidney failure, it is typically detected in patients receiving dialysis, with an increasing frequency ranging from 1% to 4%. Therefore, the disease is also known as calcific uremic arteriolopathy.
View Article and Find Full Text PDFLayer Cake Granulomas: A Case of Calciphylaxis Coexisting With Necrobiosis Lipoidica.
Can J Diabetes
October 2021
St Joseph Mercy Oakland Hospital, Pontiac, Michigan, United States. Electronic address:
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