Utility of hybrid whole genome sequencing in assessing potential nosocomial VIM transmission.

Antimicrob Steward Healthc Epidemiol

Department of Community Health and Epidemiology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada.

Published: August 2024

Hybrid whole genome sequencing was used to investigate if nosocomial Verona integron-encoded metallo-β-lactamase (VIM) carbapenemase transmission occurred between two patients without epidemiological links or common pathogens. Challenges in genomic methodology and appropriate analytical depth for mobile carbapenemase outbreaks are described including how inappropriate choices can mislead results and impact infection control practices.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736459PMC
http://dx.doi.org/10.1017/ash.2024.347DOI Listing

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