Rapid (≤25 °C) cycloisomerization of anhydride-tethered triynes to benzynes - origin of a remarkable anhydride linker-induced rate enhancement.

The hexadehydro-Diels-Alder (HDDA) reaction is a cycloisomerization between a conjugated diyne and a tethered diynophile that generates -benzyne derivatives. Considerable fundamental understanding of aryne reactivity has resulted from this body of research. The multi-yne cycloisomerization substrate is typically pre-formed and the (rate-limiting) closure of this diyne/diynophile pair to produce the isomeric benzyne generally requires thermal input, often requiring reaction temperatures of >100 °C and times of 16-48 h to achieve near-full conversion. We report here that diynoic acids can be dimerized and that the resulting substrate, having a 3-atom anhydride linker (, O[double bond, length as m-dash]COC[double bond, length as m-dash]O), then undergoes HDDA cyclization within minutes at or below room temperature. This allows for the novel assembly and cyclization of HDDA benzyne precursors in an operationally simple protocol. Experimental kinetic data along with DFT computations are used to identify the source of this surprisingly huge rate acceleration afforded by the anhydride linker: >10 faster than the analogous multi-yne having, instead, a CHOCH ether linker.