A novel mechanochemical approach is described for chloride-templated head-to-tail macrocyclization of a pentapeptide and a hexapeptide. This straightforward method allows the solvent-free preparation of cyclopeptides with yields comparable to solution-based approaches without the need for high dilution of the reaction mixture and with significantly reduced reaction times and organic waste amount.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734432 | PMC |
| http://dx.doi.org/10.1021/acssuschemeng.4c03309 | DOI Listing |
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