Utilizing a Novel Convolutional Neural Network for Diagnosis and Lesion Delineation in Colorectal Cancer Screening.

J Imaging Inform Med

School of Control Science and Engineering, Shandong University, Jinan, 250012, Shandong, China.

Published: January 2025

Early detection of colorectal cancer is vital for enhancing cure rates and alleviating treatment burdens. Nevertheless, the high demand for screenings coupled with a limited number of endoscopists underscores the necessity for advanced deep learning techniques to improve screening efficiency and accuracy. This study presents an innovative convolutional neural network (CNN) model, trained on 8260 images from screenings conducted at four medical institutions. The model incorporates parallel global and local feature extraction branches and a distinctive classification head, facilitating both cancer classification and the creation of heatmaps that outline cancerous lesion regions. Performance evaluations of the CNN model, measured against five leading models using accuracy, precision, recall, and F1 score, revealed its superior efficacy across these metrics. Furthermore, the heatmaps proved effective in aiding the automatic identification of lesion locations. In summary, this CNN model represents a promising advancement in early colorectal cancer screening, delivering precise, swift diagnostic results and robust interpretability through its automatic lesion highlighting capabilities.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10278-025-01396-8DOI Listing

Publication Analysis

Top Keywords

colorectal cancer
12
cnn model
12
convolutional neural
8
neural network
8
cancer screening
8
utilizing novel
4
novel convolutional
4
network diagnosis
4
lesion
4
diagnosis lesion
4

Similar Publications

In this study, a novel inhibitor of ERCC1/XPF heterodimerization, A4, was used as an inhibitor of repair for DNA damage by platinum-based chemotherapeutics. Nano-formulations of A4 were developed, using self-assembly of the following block copolymers: methoxy-poly(ethylene oxide)-block-poly(α-benzyl carboxylate-ε-caprolactone) (PEO-b-PBCL), methoxy-poly(ethylene oxide)-block-poly(ε-caprolactone) (PEO-b-PCL), or methoxy-poly(ethylene oxide)-block-poly (D, L, lactide) (PEO-b-PDLA 50-50). The nano-formulations were characterized for their average diameter, polydispersity, morphology, A4 encapsulation and in vitro release.

View Article and Find Full Text PDF

PD-L1/PD-1 checkpoint inhibitors (CPIs) are mainstream agents for cancer immunotherapy, but the prognosis is unsatisfactory in solid tumor patients lacking preexisting T-cell reactivity. Adjunct therapy strategies including the intratumoral administration of immunostimulants aim to address this limitation. CpG oligodeoxynucleotides (ODNs), TLR9 agonists that can potentiate adaptive immunity, have been widely investigated to tackle PD-L1/PD-1 resistance, but clinical success has been hindered by inconsistent efficacy and immune-related toxicities caused by systemic exposure.

View Article and Find Full Text PDF

Purpose: This meta-analysis aims to estimate the global prevalence of severe, moderate, overall malnutrition and moderating factors of malnutrition in colorectal cancer (CRC) survivors.

Methods: A comprehensive search was conducted in Embase, CINAHL, Medline-OVID, PubMed, Scopus, and Web of Science from inception to February 8, 2024, without language, region, or publication date restrictions. A generalized linear mixed model and random-effects model were used to examine the pooled prevalence, and moderator analyses were implemented to investigate variations in the pooled prevalence.

View Article and Find Full Text PDF

Gold nanocomposites in colorectal cancer therapy: characterization, selective cytotoxicity, and migration inhibition.

Naunyn Schmiedebergs Arch Pharmacol

January 2025

Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, UCSI University, No. 1, Jalan Menara Gading, Taman Connaught, Cheras, Kuala Lumpur, 56000, Malaysia.

The third most prevalent type of cancer in the world, colorectal cancer, poses a significant treatment challenge due to the nonspecific distribution, low efficacy, and high systemic toxicity associated with chemotherapy. To overcome these limitations, a targeted drug delivery system with a high cytotoxicity against cancer cells while maintaining a minimal systemic side effects represents a promising therapeutic approach. Therefore, the aim of this study was to develop an efficient gold nanocarrier for the targeted delivery of the anticancer agent everolimus to Caco-2 cells.

View Article and Find Full Text PDF

Monotropein (Mon) is an iridoid glycosides extracted from Morinda officinalis F.C. How.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!