Unilateral and Bilateral Disulfurating Reagents for the Synthesis of Unsymmetrical Polysulfides.

Polysulfides play an essential role across a variety of fields, including life sciences, pharmaceuticals, food science, and materials science. However, the controlled sequential installation of groups at both ends of an S-S motif poses enormous challenges due to the reversible nature of the covalent S-S bond. The application of unique disulfide reagents presents one of the most straightforward approaches for constructing diverse polysulfides. This concept highlights the initiatives and advancements in polysulfide synthesis facilitated by unilateral or bilateral disulfide reagents. Furthermore, ongoing research is focused on recently reported methodologies for synthesizing unsymmetrical disulfides.