Metal-Organic Frameworks MIL-101(Fe) and MIL-53(Al) as Efficient Adsorbents for Dispersive Micro-Solid-Phase Extraction of Sorafenib in Plasma and Wastewater, Coupled with HPLC-UV Analysis.

In the present study, metal-organic frameworks, MIL-101(Fe) and MIL-53(Al), were synthesized under solvothermal conditions and were characterized by Fourier transform infrared spectroscopy, X-ray energy diffraction spectroscopy and scanning electron microscopy. The synthesized metal-organic frameworks were utilized for the purpose of dispersive micro-solid phase extraction of sorafenib in both human plasma and wastewater, which was subsequently followed by high performance liquid chromatography with ultraviolet determination. Parameters affecting extraction efficacy including adsorbent amount, ionic strength, pH, type of elution solvent, adsorption and desorption time were optimized. Under optimal experimental conditions, the linearity in human plasma and wastewater was achieved in the range of 0.25-5.00 and 0.01-0.20 μg/mL, respectively. The extraction recovery for MIL-101(Fe) and MIL-53(Al), respectively, was calculated in human plasma and wastewater and found to be in the range of 86.27-99.47%.