Arylacetic acid equivalents bearing a pyridine group undergo C(sp)-H/C(sp)-H cross coupling with diverse methylarenes in the presence of a copper based catalyst system. The reaction proceeds the formation of α-carbonyl radicals giving access to α,β-diarylpropionic acids. Preliminary study suggests that the catalyst system is capable of transforming arylbenzyl ketones into 1,2,3-triaryl ketones.
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Copper catalyzed C(sp)-H/C(sp)-H cross-coupling of arylacetic acid equivalents with methylarenes α-carbonyl radicals.
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Inorganic Materials and Catalysis Division, CSIR-Central Salt and Marine Chemicals Research Institute, G.B. Marg, Bhavnagar 364002, Gujarat, India.
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